Radiosynthesis and Biological Evaluation of 188Re-5,10,15,20-Tetra(4-pyridyl)-21H,23H-porphyrin Complex as a Tumor-Targeting Agent

被引：0

作者：

M. H. Sanad

A. B. Farag

G. M. Saleh

机构：

[1] Atomic Energy Authority,Labeled Compounds Department, Hot Laboratories Center

[2] Ahram Canadian University,Pharmaceutical Chemistry Department, Faculty of Pharmacy

[3] Atomic Energy Authority,Health Radiation Research Department (Radiodiagnosis Unit), National Center for Radiation Research and Technology

来源：

Radiochemistry | 2019年 / 61卷

关键词：

rhenium-188; labeling; tumor; porphyrin; biodistribution;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

188Re-5,10,15,20-tetra(4-pyridyl)-21H,23H-porphyrin, [188Re]TMPP, a tumor-targeted agent, was prepared. Under optimum conditions, the 188Re-TMPP yield after purification exceeded 98%. Biodistribution studies showed high tumor uptake of the agent within 30 min post injection (17.5 ± 1.1% ID/g) for Swiss Albino mice bearing Ehrlich ascites carcinoma (EAC). [188Re]TMPP can be considered as a highly selective radiotracer for highly replicating solid tumors.

引用

页码：347 / 351

页数：4