Radiosynthesis and Biological Evaluation of 188Re-5,10,15,20-Tetra(4-pyridyl)-21H,23H-porphyrin Complex as a Tumor-Targeting Agent

被引：0
|
作者：
M. H. Sanad
A. B. Farag
G. M. Saleh
机构：
[1] Atomic Energy Authority,Labeled Compounds Department, Hot Laboratories Center
[2] Ahram Canadian University,Pharmaceutical Chemistry Department, Faculty of Pharmacy
[3] Atomic Energy Authority,Health Radiation Research Department (Radiodiagnosis Unit), National Center for Radiation Research and Technology
来源：
Radiochemistry | 2019年 / 61卷
关键词：
rhenium-188; labeling; tumor; porphyrin; biodistribution;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
188Re-5,10,15,20-tetra(4-pyridyl)-21H,23H-porphyrin, [188Re]TMPP, a tumor-targeted agent, was prepared. Under optimum conditions, the 188Re-TMPP yield after purification exceeded 98%. Biodistribution studies showed high tumor uptake of the agent within 30 min post injection (17.5 ± 1.1% ID/g) for Swiss Albino mice bearing Ehrlich ascites carcinoma (EAC). [188Re]TMPP can be considered as a highly selective radiotracer for highly replicating solid tumors.
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页码：347 / 351
页数：4
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