Radiosynthesis and Biological Evaluation of 188Re-5,10,15,20-Tetra(4-pyridyl)-21H,23H-porphyrin Complex as a Tumor-Targeting Agent

被引：0

作者：

M. H. Sanad

A. B. Farag

G. M. Saleh

机构：

[1] Atomic Energy Authority,Labeled Compounds Department, Hot Laboratories Center

[2] Ahram Canadian University,Pharmaceutical Chemistry Department, Faculty of Pharmacy

[3] Atomic Energy Authority,Health Radiation Research Department (Radiodiagnosis Unit), National Center for Radiation Research and Technology

来源：

Radiochemistry | 2019年 / 61卷

关键词：

rhenium-188; labeling; tumor; porphyrin; biodistribution;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

188Re-5,10,15,20-tetra(4-pyridyl)-21H,23H-porphyrin, [188Re]TMPP, a tumor-targeted agent, was prepared. Under optimum conditions, the 188Re-TMPP yield after purification exceeded 98%. Biodistribution studies showed high tumor uptake of the agent within 30 min post injection (17.5 ± 1.1% ID/g) for Swiss Albino mice bearing Ehrlich ascites carcinoma (EAC). [188Re]TMPP can be considered as a highly selective radiotracer for highly replicating solid tumors.

引用

页码：347 / 351

页数：4

共 41 条

[1] Radiosynthesis and Biological Evaluation of 188Re-5,10,15,20-Tetra(4-pyridyl)-21H,23H-porphyrin Complex as a Tumor-Targeting Agent
Sanad, M. H.
Farag, A. B.
Saleh, G. M.
RADIOCHEMISTRY, 2019, 61 (03) : 347 - 351
[2] Reverse saturable absorption in 5,10,15,20-tetra(4-pyridyl)-21H,23H-porphyrin with ruthenium outlying complexes
Neto, Newton M. Barbosa
Oliveira, Samuel L.
Guedes, Ilde
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Misoguti, Lino
Mendonca, Cleber R.
Batista, Alzir A.
Zilio, Sergio C.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2006, 17 (07) : 1377 - 1382
[3] Investigation of Ground- and Excited-State Photophysical Properties of 5,10,15,20-Tetra(4-pyridyl)-21H,23H-porphyrin with Ruthenium Outlying Complexes
Sampaio, R. N.
Gomes, W. R.
Araujo, D. M. S.
Machado, A. E. H.
Silva, R. A.
Marletta, A.
Borissevitch, I. E.
Ito, A. S.
Dinelli, L. R.
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Zilio, S. C.
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Barbosa Neto, N. M.
JOURNAL OF PHYSICAL CHEMISTRY A, 2012, 116 (01): : 18 - 26
[4] INFLUENCE OF 5,10,15,20-TETRAKIS(4-PYRIDYL)-21H,23H-PORPHYRIN ON THE CORROSION OF STEEL IN AQUEOUS SULFURIC ACID
Fagadar-Cosmaa, G.
Taranu, B. O.
Birdeanu, M.
Popescu, M.
Fagadar-Cosma, E.
DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES, 2014, 9 (02) : 551 - 557
[5] Self-assembled monolayers formed by 5,10,15,20-tetra(4-pyridyl)porphyrin and cobalt 5,10,15,20-tetra(4-pyridyl)-21H,23H-porphine on iodine-passivated Au(111) as observed using electrochemical scanning tunneling microscopy and cyclic voltammetry
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2012, 664 : 94 - 99
[6] Colorimetric ascorbic acid sensing from a synergetic catalytic strategy based on 5,10,15,20-tetra(4-pyridyl)-21H,23H-porphyrin functionalized CuS nanohexahedrons with the enhanced peroxidase-like activity
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Yang, Zhongdong
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Liu, Qingyun
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2020, 598
[7] Photoinduced Chemiluminescence Determination of Prednisolone Using Lucigenin-Cobalt 5,10,15,20-Tetra(4-Pyridyl)-21H,23H-Porphine System
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LUMINESCENCE, 2025, 40 (01)
[8] Silver(I)-selective PVC membrane potentiometric sensor based on 5,10,15,20-tetra(4-pyridyl)-21H, 23H-porphine and potentiometric applications
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Journal of Chemical Sciences, 2020, 132
[9] Tuning of structural and optical properties of 5,10,15,20-tetra(4-pyridyl)-21H,23H-porphine thin films as a promising photovoltaic absorber material
Makhlouf, M. M.
Shehata, M. M.
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OPTICAL MATERIALS, 2019, 98
[10] 5,10,15,20-Tetra(4-pyridyl)-21H,23H-porphine as an effective corrosion inhibitor for N80 steel in 3.5% NaCl solution
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INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE, 2014, 9 (12): : 7495 - 7505

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