A Compound isolated from Rumex japonicus induces early growth response gene-1 expression

被引：2

作者：

Geunhyeong Jo

Soon Young Shin

Younggiu Lee

Jiye Hyun

Kwang Sik Dong

Jun Cheol Park

Hyun Su Kim

Young Han Lee

Yoongho Lim

机构：

[1] Konkuk University,Division of Bioscience and Biotechnology, BMIC

[2] Konkuk University,Department of Biomedical Science and Technology, RCTC, SMART Institute of Advanced Biomedical Science

[3] National Institute of Animal Science,Rural Development Administration

[4] International University of Korea,Department of Pharmaceutical Engineering

来源：

Journal of the Korean Society for Applied Biological Chemistry | 2011年 / 54卷

关键词：

clonogenic assay; early growth response-1 gene; flavonoid; parietin;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A compound was isolated from the root of Rumex japonicus. Based on spectroscopic data including nuclear magnetic resonance spectroscopy and mass spectrometry, the chemical structure of the compound was determined to be 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione. The compound exhibits antitumor activity due to inhibition of clonogenicity and induction of tumor suppressor early growth response gene-1 in HCT116 colon cancer cells.

引用

页码：637 / 643

页数：6

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