A Compound isolated from Rumex japonicus induces early growth response gene-1 expression

被引：2
|
作者：
Geunhyeong Jo
Soon Young Shin
Younggiu Lee
Jiye Hyun
Kwang Sik Dong
Jun Cheol Park
Hyun Su Kim
Young Han Lee
Yoongho Lim
机构：
[1] Konkuk University,Division of Bioscience and Biotechnology, BMIC
[2] Konkuk University,Department of Biomedical Science and Technology, RCTC, SMART Institute of Advanced Biomedical Science
[3] National Institute of Animal Science,Rural Development Administration
[4] International University of Korea,Department of Pharmaceutical Engineering
来源：
Journal of the Korean Society for Applied Biological Chemistry | 2011年 / 54卷
关键词：
clonogenic assay; early growth response-1 gene; flavonoid; parietin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A compound was isolated from the root of Rumex japonicus. Based on spectroscopic data including nuclear magnetic resonance spectroscopy and mass spectrometry, the chemical structure of the compound was determined to be 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione. The compound exhibits antitumor activity due to inhibition of clonogenicity and induction of tumor suppressor early growth response gene-1 in HCT116 colon cancer cells.
引用
收藏
页码：637 / 643
页数：6
相关论文
共 50 条
  • [21] DETECTION OF EARLY GROWTH-RESPONSE GENE-1 (EGR-1) EXPRESSION IN SYNOVIAL TISSUE BY INSITU-HYBRIDIZATION
    HEER, AH
    KEYSZER, GM
    SUKHATME, VP
    GAY, S
    ARTHRITIS AND RHEUMATISM, 1993, 36 (05): : R20 - R20
  • [22] MITOGENIC SIGNALS CONTROL TRANSLATION OF THE EARLY GROWTH-RESPONSE GENE-1 IN MYOGENIC CELLS
    MAASS, A
    GROHE, C
    OBERDORF, S
    SUKHATME, VP
    VETTER, H
    NEYSES, L
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 202 (03) : 1337 - 1346
  • [23] Transcriptional control of cardiac allograft vasculopathy by early growth response gene-1 (Egr-1)
    Okada, M
    Wang, CY
    Hwang, DW
    Sakaguchi, T
    Olson, KE
    Yoshikawa, Y
    Minamoto, K
    Mazer, SP
    Yan, SF
    Pinsky, DJ
    CIRCULATION RESEARCH, 2002, 91 (02) : 135 - 142
  • [24] Glucose induces early growth response gene (Egr-1) expression in pancreatic beta cells
    K. Josefsen
    L. R. Sørensen
    K. Buschard
    M. Birkenbach
    Diabetologia, 1999, 42 : 195 - 203
  • [25] Glucose induces early growth response gene (Egr-1) expression in pancreatic beta cells
    Josefsen, K
    Sorensen, LR
    Buschard, K
    Birkenbach, M
    DIABETOLOGIA, 1999, 42 (02) : 195 - 203
  • [26] Mechanisms of myocardial gene regulation by estrogen (E2):: E2 induces α-myosin heavy chain expression in the myocardium via the early growth response gene-1 (EGR-1).
    De Jager, T
    Pelzer, T
    Mueller-Botz, S
    Muck, J
    Neyses, L
    CIRCULATION, 2000, 102 (18) : 134 - 134
  • [27] ANGIOTENSIN-II INDUCES FORMATION OF THE EARLY GROWTH-RESPONSE GENE-1 PROTEIN IN RAT VASCULAR SMOOTH-MUSCLE CELLS
    SACHINIDIS, A
    WEISSER, P
    KO, Y
    SCHULTE, K
    BRICKWEDDE, KMZ
    NEYSES, L
    VETTER, H
    FEBS LETTERS, 1992, 313 (02) : 109 - 112
  • [28] INDUCTION OF MYOCARDIAL HYPERTROPHY BY GROWTH-FACTORS - ROLE OF THE EARLY GROWTH-RESPONSE GENE-1 (EGR-1)
    NEYSES, L
    OBERDORF, S
    VETTER, H
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1992, 24 : S58 - S58
  • [29] Expression of early growth responsive gene-1 in the visual cortex of monocular form deprivation amblyopic kittens
    Haobo Fan
    Ying Wang
    Xiuping Tang
    Liyuan Yang
    Weiqi Song
    Yunchun Zou
    BMC Ophthalmology, 21
  • [30] The cytoskeleton differentially localizes the early growth response gene-1 protein in cancer and benign cells of the prostate
    Mora, GR
    Olivier, KR
    Cheville, JC
    Mitchell, RF
    Lingle, WL
    Tindall, DJ
    MOLECULAR CANCER RESEARCH, 2004, 2 (02) : 115 - 128
12345