Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

被引：0

作者：

Zhentao Zhang

Mingke Song

Xia Liu

Seong Su Kang

Il-Sun Kwon

Duc M Duong

Nicholas T Seyfried

William T Hu

Zhixue Liu

Jian-Zhi Wang

Liming Cheng

Yi E Sun

Shan Ping Yu

Allan I Levey

Keqiang Ye

机构：

[1] Emory University School of Medicine,Department of Pathology and Laboratory Medicine

[2] Renmin Hospital of Wuhan University,Department of Neurology

[3] Emory University School of Medicine,Department of Anesthesiology

[4] Emory University School of Medicine,Department of Biochemistry

[5] Center for Neurodegenerative Diseases,Department of Neurology

[6] Emory University School of Medicine,Department of Pathophysiology

[7] Emory University School of Medicine,Department of Regenerative Medicine

[8] Key Laboratory of Nutrition and Metabolism,undefined

[9] Institute for Nutritional Sciences,undefined

[10] Shanghai Institutes for Biological Sciences,undefined

[11] Chinese Academy of Sciences,undefined

[12] Graduate School of the Chinese Academy of Sciences,undefined

[13] Key Laboratory of Ministry of Education of Neurological Diseases,undefined

[14] Tongji Medical College,undefined

[15] Huazhong University of Science and Technology,undefined

[16] Translational Center for Stem Cell Research,undefined

[17] Tongji Hospital,undefined

[18] Tongji University School of Medicine,undefined

来源：

Nature Medicine | 2014年 / 20卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Tau cleavage and aggregation, key processes in many neurodegenerative diseases, can be reduced by blocking the activity of a protease called asparagine endopeptidase.

引用

页码：1254 / 1262

页数：8

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