Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

被引：0
|
作者：
Zhentao Zhang
Mingke Song
Xia Liu
Seong Su Kang
Il-Sun Kwon
Duc M Duong
Nicholas T Seyfried
William T Hu
Zhixue Liu
Jian-Zhi Wang
Liming Cheng
Yi E Sun
Shan Ping Yu
Allan I Levey
Keqiang Ye
机构：
[1] Emory University School of Medicine,Department of Pathology and Laboratory Medicine
[2] Renmin Hospital of Wuhan University,Department of Neurology
[3] Emory University School of Medicine,Department of Anesthesiology
[4] Emory University School of Medicine,Department of Biochemistry
[5] Center for Neurodegenerative Diseases,Department of Neurology
[6] Emory University School of Medicine,Department of Pathophysiology
[7] Emory University School of Medicine,Department of Regenerative Medicine
[8] Key Laboratory of Nutrition and Metabolism,undefined
[9] Institute for Nutritional Sciences,undefined
[10] Shanghai Institutes for Biological Sciences,undefined
[11] Chinese Academy of Sciences,undefined
[12] Graduate School of the Chinese Academy of Sciences,undefined
[13] Key Laboratory of Ministry of Education of Neurological Diseases,undefined
[14] Tongji Medical College,undefined
[15] Huazhong University of Science and Technology,undefined
[16] Translational Center for Stem Cell Research,undefined
[17] Tongji Hospital,undefined
[18] Tongji University School of Medicine,undefined
来源：
Nature Medicine | 2014年 / 20卷
关键词：
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学科分类号：
摘要：
Tau cleavage and aggregation, key processes in many neurodegenerative diseases, can be reduced by blocking the activity of a protease called asparagine endopeptidase.
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页码：1254 / 1262
页数：8
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