Thalamic projections sustain prefrontal activity during working memory maintenance

被引：0

作者：

Scott S Bolkan

Joseph M Stujenske

Sebastien Parnaudeau

Timothy J Spellman

Caroline Rauffenbart

Atheir I Abbas

Alexander Z Harris

Joshua A Gordon

Christoph Kellendonk

机构：

[1] Graduate Program in Neurobiology and Behavior,Department of Psychiatry

[2] Columbia University,Department of Pharmacology

[3] College of Physicians and Surgeons,Division of Integrative Neuroscience

[4] Sorbonne Universités,Division of Molecular Therapeutics

[5] UPMC Paris 06,undefined

[6] Institut de Biologie Paris Seine,undefined

[7] UM119,undefined

[8] Neuroscience Paris Seine,undefined

[9] CNRS UMR8246,undefined

[10] INSERM U1130,undefined

[11] Feil Family Brain and Mind Research Institute,undefined

[12] Weill Cornell Medical College,undefined

[13] Columbia University,undefined

[14] College of Physicians and Surgeons,undefined

[15] Columbia University,undefined

[16] College of Physicians and Surgeons,undefined

[17] New York State Psychiatric Institute,undefined

[18] New York State Psychiatric Institute,undefined

[19] National Institute of Mental Health,undefined

[20] Office of the Director,undefined

来源：

Nature Neuroscience | 2017年 / 20卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Using pathway-specific optogenetic inhibition, the authors demonstrate that projections from the mediodorsal thalamus to prefrontal cortex support the maintenance of working memory, while prefrontal–thalamic projections support subsequent choice selection. Thalamo–prefrontal projections have a circuit-specific role in sustaining prefrontal delay-period activity, a neuronal signature required for successful task performance.

引用

页码：987 / 996

页数：9

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