Thalamic projections sustain prefrontal activity during working memory maintenance

被引：0

作者：

Scott S Bolkan

Joseph M Stujenske

Sebastien Parnaudeau

Timothy J Spellman

Caroline Rauffenbart

Atheir I Abbas

Alexander Z Harris

Joshua A Gordon

Christoph Kellendonk

机构：

[1] Graduate Program in Neurobiology and Behavior,Department of Psychiatry

[2] Columbia University,Department of Pharmacology

[3] College of Physicians and Surgeons,Division of Integrative Neuroscience

[4] Sorbonne Universités,Division of Molecular Therapeutics

[5] UPMC Paris 06,undefined

[6] Institut de Biologie Paris Seine,undefined

[7] UM119,undefined

[8] Neuroscience Paris Seine,undefined

[9] CNRS UMR8246,undefined

[10] INSERM U1130,undefined

[11] Feil Family Brain and Mind Research Institute,undefined

[12] Weill Cornell Medical College,undefined

[13] Columbia University,undefined

[14] College of Physicians and Surgeons,undefined

[15] Columbia University,undefined

[16] College of Physicians and Surgeons,undefined

[17] New York State Psychiatric Institute,undefined

[18] New York State Psychiatric Institute,undefined

[19] National Institute of Mental Health,undefined

[20] Office of the Director,undefined

来源：

Nature Neuroscience | 2017年 / 20卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Using pathway-specific optogenetic inhibition, the authors demonstrate that projections from the mediodorsal thalamus to prefrontal cortex support the maintenance of working memory, while prefrontal–thalamic projections support subsequent choice selection. Thalamo–prefrontal projections have a circuit-specific role in sustaining prefrontal delay-period activity, a neuronal signature required for successful task performance.

引用

页码：987 / 996

页数：9

共 50 条

[21] Persistent neural activity during the maintenance of spatial position in working memory
Srimal, Riju
Curtis, Clayton E.
NEUROIMAGE, 2008, 39 (01) : 455 - 468
[22] Deficit in sustained activity in the DLPFC during working memory maintenance in schizophrenia
Yoon, Jong H.
Carter, Cameron S.
NEUROPSYCHOPHARMACOLOGY, 2006, 31 : S177 - S177
[23] Sustained activity deficits during spatial working memory maintenance in schizophrenia
Driesen, NR
Leung, HC
Constable, RT
Skudlarski, P
Hoffman, R
Krystal, JH
Goldman-Rakic, PS
BIOLOGICAL PSYCHIATRY, 2005, 57 (08) : 205S - 205S
[24] The contribution of medial prefrontal cortex neurons and their subcortical projections to spatial working memory
Vogel, P.
Duvarci, S.
Sigurdsson, T.
ACTA PHYSIOLOGICA, 2022, 236 : 193 - 195
[25] Age differences in prefrontal cortical activity in working memory
Rypma, B
Prabhakaran, V
Desmond, JE
Gabrieli, JDE
PSYCHOLOGY AND AGING, 2001, 16 (03) : 371 - 384
[26] GENERAL PLAN OF THE THALAMIC PROJECTIONS TO THE PREFRONTAL CORTEX IN THE CAT
MARTINEZMORENO, E
LLAMAS, A
AVENDANO, C
RENES, E
REINOSOSUAREZ, F
BRAIN RESEARCH, 1987, 407 (01) : 17 - 26
[27] Linear and nonlinear prefrontal and parietal activity during multiple-item working memory
Yi, Yuji
Leung, Hoi-Chung
NEUROIMAGE, 2011, 57 (03) : 1281 - 1291
[28] Prefrontal oscillatory activity in human magnetoencephalogram during working memory for brief sound durations
Kaiser, J
Leiberg, S
Rust, H
Lutzenberger, W
JOURNAL OF PSYCHOPHYSIOLOGY, 2006, 20 (02) : 128 - 129
[29] Medial prefrontal activity during delay period contributes to learning of a working memory task
Liu, Ding
Gu, Xiaowei
Zhu, Jia
Zhang, Xiaoxing
Han, Zhe
Yan, Wenjun
Cheng, Qi
Hao, Jiang
Fan, Hongmei
Hou, Ruiqing
Chen, Zhaoqin
Chen, Yulei
Li, Chengyu T.
SCIENCE, 2014, 346 (6208) : 458 - 463
[30] A recurrent neural network model of prefrontal brain activity during a working memory task
Piwek, Emilia P.
Stokes, Mark G.
Summerfield, Christopher
PLOS COMPUTATIONAL BIOLOGY, 2023, 19 (10)

← 1 2 3 4 5 →