Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus

被引：0
|
作者：
Mark H. T. Stappers
Alexandra E. Clark
Vishukumar Aimanianda
Stefan Bidula
Delyth M. Reid
Patawee Asamaphan
Sarah E. Hardison
Ivy M. Dambuza
Isabel Valsecchi
Bernhard Kerscher
Anthony Plato
Carol A. Wallace
Raif Yuecel
Betty Hebecker
Maria da Glória Teixeira Sousa
Cristina Cunha
Yan Liu
Ten Feizi
Axel A. Brakhage
Kyung J. Kwon-Chung
Neil A. R. Gow
Matteo Zanda
Monica Piras
Chiara Zanato
Martin Jaeger
Mihai G. Netea
Frank L. van de Veerdonk
João F. Lacerda
António Campos
Agostinho Carvalho
Janet A. Willment
Jean-Paul Latgé
Gordon D. Brown
机构：
[1] Medical Research Council Centre for Medical Mycology at the University of Aberdeen,Department of Medicine
[2] Aberdeen Fungal Group,Department of Microbiology and Molecular Biology
[3] Institute of Medical Sciences,Department of Internal Medicine
[4] Unité des Aspergillus,State Key Laboratory
[5] Institut Pasteur,undefined
[6] Iain Fraser Cytometry Centre,undefined
[7] Institute of Medical Sciences,undefined
[8] University of Aberdeen,undefined
[9] Life and Health Sciences Research Institute (ICVS),undefined
[10] School of Medicine,undefined
[11] University of Minho,undefined
[12] ICVS/3B’s – PT Government Associate Laboratory,undefined
[13] Glycosciences Laboratory,undefined
[14] Imperial College London,undefined
[15] Leibniz Institute for Natural Product Research and Infection Biology (HKI),undefined
[16] Friedrich Schiller University,undefined
[17] Molecular Microbiology Section,undefined
[18] Laboratory of Clinical Immunology and Microbiology,undefined
[19] National Institute of Allergy and Infectious Diseases (NIAID),undefined
[20] National Institutes of Health (NIH),undefined
[21] Institute of Medical Sciences,undefined
[22] University of Aberdeen,undefined
[23] Radboud University Medical Center,undefined
[24] Instituto de Medicina Molecular,undefined
[25] Faculdade de Medicina de Lisboa,undefined
[26] Universidade de Lisboa,undefined
[27] Serviço de Hematologia e Transplantação de Medula,undefined
[28] Hospital de Santa Maria,undefined
[29] Serviço de Transplantação de Medula Óssea (STMO),undefined
[30] Instituto Português de Oncologia do Porto,undefined
[31] Institute of Microbiology,undefined
[32] Chinese Academy of Sciences,undefined
来源：
Nature | 2018年 / 555卷
关键词：
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学科分类号：
摘要：
The C-type lectin receptor MelLec recognizes DHN-melanin in conidial spores of Aspergillus fumigatus and other DHN-melanized fungi, revealing an important role for this receptor in antifungal immunity in both mice and humans.
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页码：382 / 386
页数：4
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