Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus

被引：0

作者：

Mark H. T. Stappers

Alexandra E. Clark

Vishukumar Aimanianda

Stefan Bidula

Delyth M. Reid

Patawee Asamaphan

Sarah E. Hardison

Ivy M. Dambuza

Isabel Valsecchi

Bernhard Kerscher

Anthony Plato

Carol A. Wallace

Raif Yuecel

Betty Hebecker

Maria da Glória Teixeira Sousa

Cristina Cunha

Yan Liu

Ten Feizi

Axel A. Brakhage

Kyung J. Kwon-Chung

Neil A. R. Gow

Matteo Zanda

Monica Piras

Chiara Zanato

Martin Jaeger

Mihai G. Netea

Frank L. van de Veerdonk

João F. Lacerda

António Campos

Agostinho Carvalho

Janet A. Willment

Jean-Paul Latgé

Gordon D. Brown

机构：

[1] Medical Research Council Centre for Medical Mycology at the University of Aberdeen,Department of Medicine

[2] Aberdeen Fungal Group,Department of Microbiology and Molecular Biology

[3] Institute of Medical Sciences,Department of Internal Medicine

[4] Unité des Aspergillus,State Key Laboratory

[5] Institut Pasteur,undefined

[6] Iain Fraser Cytometry Centre,undefined

[7] Institute of Medical Sciences,undefined

[8] University of Aberdeen,undefined

[9] Life and Health Sciences Research Institute (ICVS),undefined

[10] School of Medicine,undefined

[11] University of Minho,undefined

[12] ICVS/3B’s – PT Government Associate Laboratory,undefined

[13] Glycosciences Laboratory,undefined

[14] Imperial College London,undefined

[15] Leibniz Institute for Natural Product Research and Infection Biology (HKI),undefined

[16] Friedrich Schiller University,undefined

[17] Molecular Microbiology Section,undefined

[18] Laboratory of Clinical Immunology and Microbiology,undefined

[19] National Institute of Allergy and Infectious Diseases (NIAID),undefined

[20] National Institutes of Health (NIH),undefined

[21] Institute of Medical Sciences,undefined

[22] University of Aberdeen,undefined

[23] Radboud University Medical Center,undefined

[24] Instituto de Medicina Molecular,undefined

[25] Faculdade de Medicina de Lisboa,undefined

[26] Universidade de Lisboa,undefined

[27] Serviço de Hematologia e Transplantação de Medula,undefined

[28] Hospital de Santa Maria,undefined

[29] Serviço de Transplantação de Medula Óssea (STMO),undefined

[30] Instituto Português de Oncologia do Porto,undefined

[31] Institute of Microbiology,undefined

[32] Chinese Academy of Sciences,undefined

来源：

Nature | 2018年 / 555卷

关键词：

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学科分类号：

摘要：

The C-type lectin receptor MelLec recognizes DHN-melanin in conidial spores of Aspergillus fumigatus and other DHN-melanized fungi, revealing an important role for this receptor in antifungal immunity in both mice and humans.

引用

页码：382 / 386

页数：4

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