Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis

被引：0
|
作者：
Stefan Freigang
Franziska Ampenberger
Adrienne Weiss
Thirumala-Devi Kanneganti
Yoichiro Iwakura
Martin Hersberger
Manfred Kopf
机构：
[1] Institute of Molecular Health Sciences,Division of Clinical Chemistry and Biochemistry
[2] Swiss Federal Institute of Technology (ETH) Zurich,Department of Immunology
[3] University Children's Hospital,undefined
[4] St. Jude Children's Research Hospital,undefined
[5] Research Institute for Biomedical Sciences,undefined
[6] Tokyo University of Science,undefined
来源：
Nature Immunology | 2013年 / 14卷
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学科分类号：
摘要：
Chronic inflammation is a fundamental aspect of metabolic disorders such as atherosclerosis. Freigang and colleagues report that fatty acids are potent inducers of IL-1α, which drives vascular inflammation.
引用
收藏
页码：1045 / 1053
页数：8
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