Transport of Levofloxacin in the OK Kidney Epithelial Cell Line: Interaction with p-Aminohippurate Transport

被引：0
|
作者：
Yumiko Matsuo
Ikuko Yano
Yasushi Habu
Toshiya Katsura
Yukiya Hashimoto
Ken–ichi Inui
机构：
[1] Kyoto University,Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine
来源：
Pharmaceutical Research | 2001年 / 18卷
关键词：
–aminohippurate; quinolone antibacterial drugs; transcellular transport; OK cells; renal secretion; organic anion transport systems;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. To evaluate the mechanism of renal transport of quinolone antibacterial drugs, we examined the interaction of levofloxacin with p–aminohippurate (PAH) transport systems and the transport of levofloxacin in renal epithelial cells.
引用
收藏
页码：573 / 578
页数：5
相关论文
共 50 条
  • [41] RENAL BLOOD-FLOW AFTER STIMULATION OF P-AMINOHIPPURATE TRANSPORT
    FLECK, C
    BARTHA, J
    KERSTEN, L
    HABLY, C
    BRAUNLICH, H
    ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE, 1981, 252 (01): : 133 - 138
  • [42] ACETATE INFLUENCE UPON TRANSPORT KINETICS OF P-AMINOHIPPURATE AT 37DEGREESC IN RABBIT KIDNEY SLICES
    GERENCSER, GA
    CHAISETSEREE, C
    HONG, SK
    PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1977, 154 (03): : 397 - 400
  • [43] In vitro stimulation of renal tubular p-aminohippurate transport by dexamethasone in kidney tissue of immature and adult rats
    Fleck, C
    EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 1997, 49 (06) : 487 - 492
  • [44] Inhibitory effect of KW-3902, an adenosine A1 receptor antagonist, on p-aminohippurate transport in OK cells
    Nagai, JY
    Yano, I
    Habu, Y
    Katsura, T
    Hashimoto, Y
    Inui, K
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1999, 1419 (02): : 164 - 172
  • [45] INDIRECT COUPLING OF P-AMINOHIPPURATE TRANSPORT TO SODIUM IN RAT-KIDNEY BASOLATERAL MEMBRANE-VESICLES
    PRITCHARD, JB
    FASEB JOURNAL, 1988, 2 (04): : A494 - A494
  • [46] TRANSPORT OF PAH AND BETA-LACTAM ANTIBIOTICS IN THE OK KIDNEY EPITHELIAL-CELL LINE
    TAKANO, M
    NAGAI, J
    YASUHARA, M
    INUI, K
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1994, 5 (03): : 321 - 321
  • [47] P-AMINOHIPPURATE (PAH) FLUX FROM CELL TO LUMEN IN KIDNEY TUBULE
    MURTHY, L
    FOULKES, EC
    FEDERATION PROCEEDINGS, 1964, 23 (2P1) : 257 - &
  • [48] EFFECTS OF MERCURIAL DIURETICS ON RENAL TRANSPORT OF URATE AND P-AMINOHIPPURATE IN CEBUS MONKEY
    FANELLI, GM
    BOHN, DL
    REILLY, SS
    AMERICAN JOURNAL OF PHYSIOLOGY, 1973, 224 (05): : 993 - 996
  • [49] CHARACTERISTICS OF P-AMINOHIPPURATE (PAH) TRANSPORT IN ISOLATED RENAL PROXIMAL TUBULAR CELLS
    NAGINENI, CN
    LEE, DBN
    YANAGAWA, N
    FEDERATION PROCEEDINGS, 1985, 44 (06) : 1915 - 1915
  • [50] EFFECTS OF VERAPAMIL ON P-AMINOHIPPURATE (PAH) TRANSPORT BY ISOLATED, PERFUSED RENAL TUBULES
    DANTZLER, WH
    BROKL, OH
    KIDNEY INTERNATIONAL, 1984, 25 (01) : 298 - 298
12345