Active Apical Secretory Efflux of the HIV Protease Inhibitors Saquinavir and Ritonavir in Caco-2 Cell Monolayers

被引：0

作者：

Jochem Alsenz

Hans Steffen

Rainer Alex

机构：

[1] F. Hoffmann-La Roche Ltd,Preclinical Research Department, Pharma Division

[2] Grenzacherstrasse,undefined

[3] F. Hoffmann-La Roche Ltd.,undefined

[4] Grenzacherstrasse,undefined

来源：

Pharmaceutical Research | 1998年 / 15卷

关键词：

HIV protease inhibitors; saquinavir; ritonavir; Caco-2 cells; efflux system;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Purpose. To investigate in vitro the mechanisms involved in the gastrointestinal absorption of the HIV protease inhibitor, saquinavir mesylate (Invirase®), whose oral bioavailability is low, variable, and significantly increased by co-administration with ritonavir, also an HIV protease inhibitor but with higher oral bioavailability.

引用

页码：423 / 428

页数：5

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