Active Apical Secretory Efflux of the HIV Protease Inhibitors Saquinavir and Ritonavir in Caco-2 Cell Monolayers

被引：0

作者：

Jochem Alsenz

Hans Steffen

Rainer Alex

机构：

[1] F. Hoffmann-La Roche Ltd,Preclinical Research Department, Pharma Division

[2] Grenzacherstrasse,undefined

[3] F. Hoffmann-La Roche Ltd.,undefined

[4] Grenzacherstrasse,undefined

来源：

Pharmaceutical Research | 1998年 / 15卷

关键词：

HIV protease inhibitors; saquinavir; ritonavir; Caco-2 cells; efflux system;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Purpose. To investigate in vitro the mechanisms involved in the gastrointestinal absorption of the HIV protease inhibitor, saquinavir mesylate (Invirase®), whose oral bioavailability is low, variable, and significantly increased by co-administration with ritonavir, also an HIV protease inhibitor but with higher oral bioavailability.

引用

页码：423 / 428

页数：5

共 50 条

[11] Quantitative determination of saquinavir from Caco-2 cell monolayers by HPLC-UV
Ucpinar, SD
Stavchansky, S
BIOMEDICAL CHROMATOGRAPHY, 2003, 17 (01) : 21 - 25
[12] Secretory transport of ranitidine and famotidine across Caco-2 cell monolayers
Lee, KH
Ng, C
Brouwer, KLR
Thakker, DR
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 303 (02): : 574 - 580
[13] The Influence of Donor and Reservoir Additives on Caco-2 Permeability and Secretory Transport of HIV Protease Inhibitors and Other Lipophilic Compounds
Bruce J Aungst
Nhung H Nguyen
James P Bulgarelli
Kristi Oates-Lenz
Pharmaceutical Research, 2000, 17 : 1175 - 1180
[14] The influence of donor and reservoir additives on Caco-2 permeability and secretory transport of HIV protease inhibitors and other lipophilic compounds
Aungst, BJ
Nguyen, NH
Bulgarelli, JP
Oates-Lenz, K
PHARMACEUTICAL RESEARCH, 2000, 17 (10) : 1175 - 1180
[15] Effects of poly(ethylene glycol) on efflux transporter activity in Caco-2 cell monolayers
Hugger, ED
Audus, KL
Borchardt, RT
JOURNAL OF PHARMACEUTICAL SCIENCES, 2002, 91 (09) : 1980 - 1990
[16] Oleic acid decreases BCRP mediated efflux of mitoxantrone in Caco-2 cell monolayers
Aspenstrom-Fagerlund, Bitte
Tallkvist, Jonas
Ilback, Nils-Gunnar
Glynn, Anders W.
FOOD AND CHEMICAL TOXICOLOGY, 2012, 50 (10) : 3635 - 3645
[17] Disruption of Epithelial Barrier of Caco-2 Cell Monolayers by Excretory Secretory Products of Trichinella spiralis Might Be Related to Serine Protease
Li, Chengyao
Bai, Xue
Liu, Xiaolei
Zhang, Yuanyuan
Liu, Lei
Zhang, Lixiao
Xu, Fengyan
Yang, Yong
Liu, Mingyuan
FRONTIERS IN MICROBIOLOGY, 2021, 12
[18] Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical. efflux transporters in Caco-2 cell monolayers
Collnot, EM
Baldes, C
Wempe, MF
Hyatt, J
Navarro, L
Edgar, KJ
Schaefer, UF
Lehr, CM
JOURNAL OF CONTROLLED RELEASE, 2006, 111 (1-2) : 35 - 40
[19] Evaluation of Caco-2 cell permeability of ritonavir nanosuspensions
Karakucuk, Alptug
Ozturk, Naile
Celebi, Nevin
ISTANBUL JOURNAL OF PHARMACY, 2020, 50 (03): : 251 - 255
[20] pH dependent efflux of methamphetamine derivatives and their reversal through human Caco-2 cell monolayers
Crowe, Andrew
Diep, Susanna
EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 592 (1-3) : 7 - 12

← 1 2 3 4 5 →