Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets

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作者：
Magen E. Francis
Brian Richardson
Una Goncin
Mara McNeil
Melissa Rioux
Mary K. Foley
Anni Ge
Roger D. Pechous
Jason Kindrachuk
Cheryl M. Cameron
Christopher Richardson
Jocelyne Lew
Steven Machtaler
Mark J. Cameron
Volker Gerdts
Darryl Falzarano
Alyson A. Kelvin
机构：
[1] Dalhousie University,Department of Microbiology and Immunology, Faculty of Medicine
[2] University of Saskatchewan,Vaccine and Infectious Disease Organization
[3] Case Western Reserve University,International Vaccine Centre (VIDO
[4] University of Saskatchewan,InterVac)
[5] University of Arkansas for Medical Sciences,Department of Population and Quantitative Health Sciences
[6] University of Manitoba,Department of Medical Imaging
[7] Case Western Reserve University,Department of Microbiology and Immunology
[8] University of Saskatchewan,Laboratory of Emerging and Re
[9] Dalhousie University,emerging Viruses, Department of Medical Microbiology
[10] IWK Health Centre,Department of Nutrition
来源：
Scientific Reports | / 11卷
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摘要：
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) hospitalizations and deaths disportionally affect males and older ages. Here we investigated the impact of male sex and age comparing sex-matched or age-matched ferrets infected with SARS-CoV-2. Differences in temperature regulation was identified for male ferrets which was accompanied by prolonged viral replication in the upper respiratory tract after infection. Gene expression analysis of the nasal turbinates indicated that 1-year-old female ferrets had significant increases in interferon response genes post infection which were delayed in males. These results provide insight into COVID-19 and suggests that older males may play a role in viral transmission due to decreased antiviral responses.
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