Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets

被引：13

作者：

Francis, Magen E. ^{[1
,2
]}

Richardson, Brian ^{[3
]}

Goncin, Una ^{[4
]}

McNeil, Mara ^{[1
]}

Rioux, Melissa ^{[1
]}

Foley, Mary K. ^{[1
]}

Ge, Anni ^{[1
]}

Pechous, Roger D. ^{[5
]}

Kindrachuk, Jason ^{[2
,6
]}

Cameron, Cheryl M. ^{[7
]}

Richardson, Christopher ^{[1
]}

Lew, Jocelyne ^{[2
]}

Machtaler, Steven ^{[4
]}

Cameron, Mark J. ^{[3
]}

Gerdts, Volker ^{[2
,8
]}

Falzarano, Darryl ^{[2
,8
]}

Kelvin, Alyson A. ^{[1
,2
,9
,10
]}

机构：

[1] Dalhousie Univ, Fac Med, Dept Microbiol & Immunol, Halifax, NS B3H 4R2, Canada

[2] Univ Saskatchewan, Int Vaccine Ctr VIDOInterVac, Vaccine & Infect Dis Org, Saskatoon, SK S7N 5E3, Canada

[3] Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA

[4] Univ Saskatchewan, Dept Med Imaging, Saskatoon, SK S7N 0W8, Canada

[5] Univ Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA

[6] Univ Manitoba, Dept Med Microbiol, Lab Emerging & Reemerging Viruses, Winnipeg, MB R3E 0J9, Canada

[7] Case Western Reserve Univ, Dept Nutr, Cleveland, OH 44106 USA

[8] Univ Saskatchewan, Western Coll Vet Med, Dept Vet Microbiol, Saskatoon, SK S7N 5B4, Canada

[9] Dalhousie Univ, Fac Med, Div Infect Dis, Dept Pediat, Halifax, NS B3K 6R8, Canada

[10] IWK Hlth Ctr, Canadian Ctr Vaccinol, 5980 Univ Ave,4th Floor,R4020, Halifax, NS B3K 6R8, Canada

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

ACUTE RESPIRATORY SYNDROME; SARS CORONAVIRUS INFECTION; IMMUNE-RESPONSES; INFLUENZA-VIRUS; VACCINE; SUSCEPTIBILITY; PATHOGENESIS; CATS;

D O I：

10.1038/s41598-021-93855-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) hospitalizations and deaths disportionally affect males and older ages. Here we investigated the impact of male sex and age comparing sex-matched or age-matched ferrets infected with SARS-CoV-2. Differences in temperature regulation was identified for male ferrets which was accompanied by prolonged viral replication in the upper respiratory tract after infection. Gene expression analysis of the nasal turbinates indicated that 1-year-old female ferrets had significant increases in interferon response genes post infection which were delayed in males. These results provide insight into COVID-19 and suggests that older males may play a role in viral transmission due to decreased antiviral responses.

引用

页数：18

共 50 条

[1] Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets
Magen E. Francis
Brian Richardson
Una Goncin
Mara McNeil
Melissa Rioux
Mary K. Foley
Anni Ge
Roger D. Pechous
Jason Kindrachuk
Cheryl M. Cameron
Christopher Richardson
Jocelyne Lew
Steven Machtaler
Mark J. Cameron
Volker Gerdts
Darryl Falzarano
Alyson A. Kelvin
[J]. Scientific Reports, 11
[2] Age-Related Susceptibility of Ferrets to SARS-CoV-2 Infection
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