Stochastic expression dynamics of a transcription factor revealed by single-molecule noise analysis

被引：0
|
作者：
Zach Hensel
Haidong Feng
Bo Han
Christine Hatem
Jin Wang
Jie Xiao
机构：
[1] Johns Hopkins University School of Medicine,Department of Biophysics and Biophysical Chemistry
[2] Stony Brook University,Department of Chemistry and Physics
[3] State Key Laboratory of Electroanalytical Chemistry,undefined
[4] Changchun Institute of Applied Chemistry,undefined
[5] College of Physics and State Key Laboratory of Superhard Materials,undefined
[6] Jilin University,undefined
来源：
Nature Structural & Molecular Biology | 2012年 / 19卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
How intrinsic stochasticity of gene expression is controlled is not well understood. A quantitative single-molecule analysis of transcription factor expression dynamics based on a new strategy (cotranslational activation by cleavage, or CoTrAC), sheds light on the mechanisms that cells use to control noise in gene regulatory networks.
引用
收藏
页码：797 / 802
页数：5
相关论文
共 50 条
  • [31] Single-molecule imaging of transcription dynamics in somatic stem cells
    Wheat, Justin C.
    Sella, Yehonatan
    Willcockson, Michael
    Skoultchi, Arthur I.
    Bergman, Aviv
    Singer, Robert H.
    Steidl, Ulrich
    NATURE, 2020, 583 (7816) : 431 - +
  • [32] Single-molecule dynamics of transcription by human RNA Polymerase II
    Revyakin, A.
    Zhang, Z.
    Li, Y.
    Coleman, R.
    Chu, S.
    Tjian, R.
    MOLECULAR BIOLOGY OF THE CELL, 2012, 23
  • [33] Single-molecule imaging of transcription dynamics in somatic stem cells
    Justin C. Wheat
    Yehonatan Sella
    Michael Willcockson
    Arthur I. Skoultchi
    Aviv Bergman
    Robert H. Singer
    Ulrich Steidl
    Nature, 2020, 583 : 431 - 436
  • [34] Single-Molecule Imaging Reveals Dynamics of CREB Transcription Factor Bound to Its Target Sequence
    Noriyuki Sugo
    Masatoshi Morimatsu
    Yoshiyuki Arai
    Yoshinori Kousoku
    Aya Ohkuni
    Taishin Nomura
    Toshio Yanagida
    Nobuhiko Yamamoto
    Scientific Reports, 5
  • [35] Single-Molecule Imaging Reveals Dynamics of CREB Transcription Factor Bound to Its Target Sequence
    Sugo, Noriyuki
    Morimatsu, Masatoshi
    Arai, Yoshiyuki
    Kousoku, Yoshinori
    Ohkuni, Aya
    Nomura, Taishin
    Yanagida, Toshio
    Yamamoto, Nobuhiko
    SCIENTIFIC REPORTS, 2015, 5
  • [36] Single-molecule DNA biosensors for transcription-factor detection
    Lymperopoulos, K.
    Heilemann, M.
    Hwang, L. C.
    Crawford, R.
    Kapanidis, A. N.
    FEBS JOURNAL, 2008, 275 : 456 - 456
  • [37] Single-Molecule DNA Biosensors for Quantitative Transcription Factor Detection
    Crawford, Robert
    Lymperopoulos, Konstantinos
    Torella, Joseph P.
    Heilemann, Mike
    Hwang, Ling C.
    Holden, Seamus J.
    Kapanidis, Achillefs
    BIOPHYSICAL JOURNAL, 2010, 98 (03) : 611A - 611A
  • [38] Quantitative Transcription Factor Binding Kinetics at the Single-Molecule Level
    Wang, Yufang
    Guo, Ling
    Golding, Ido
    Cox, Edward C.
    Ong, N. P.
    BIOPHYSICAL JOURNAL, 2009, 96 (02) : 609 - 620
  • [39] Stochastic single-molecule dynamics of synaptic membrane protein domains
    Kahraman, Osman
    Li, Yiwei
    Haselwandter, Christoph A.
    EPL, 2016, 115 (06)
  • [40] The Evolution of the Charge Transport Mechanism in Single-Molecule Break Junctions Revealed by Flicker Noise Analysis
    Pan, Zhichao
    Chen, Lichuan
    Tang, Chun
    Hu, Yong
    Yuan, Saisai
    Gao, Tengyang
    Shi, Jie
    Shi, Jia
    Yang, Yang
    Hong, Wenjing
    SMALL, 2022, 18 (10)
12345