Stochastic expression dynamics of a transcription factor revealed by single-molecule noise analysis

被引：0
|
作者：
Zach Hensel
Haidong Feng
Bo Han
Christine Hatem
Jin Wang
Jie Xiao
机构：
[1] Johns Hopkins University School of Medicine,Department of Biophysics and Biophysical Chemistry
[2] Stony Brook University,Department of Chemistry and Physics
[3] State Key Laboratory of Electroanalytical Chemistry,undefined
[4] Changchun Institute of Applied Chemistry,undefined
[5] College of Physics and State Key Laboratory of Superhard Materials,undefined
[6] Jilin University,undefined
来源：
Nature Structural & Molecular Biology | 2012年 / 19卷
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学科分类号：
摘要：
How intrinsic stochasticity of gene expression is controlled is not well understood. A quantitative single-molecule analysis of transcription factor expression dynamics based on a new strategy (cotranslational activation by cleavage, or CoTrAC), sheds light on the mechanisms that cells use to control noise in gene regulatory networks.
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页码：797 / 802
页数：5
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