The HTLV-1 Tax interactome

被引：0
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作者：
Mathieu Boxus
Jean-Claude Twizere
Sébastien Legros
Jean-François Dewulf
Richard Kettmann
Luc Willems
机构：
[1] University Academia Wallonie-Europe,Molecular and Cellular Biology at FUSAGx
来源：
Retrovirology | / 5卷
关键词：
Bovine Leukemia Virus; Spindle Assembly Checkpoint; Centrosome Amplification; Basal Transcription Factor; Mitotic Spindle Assembly Checkpoint;
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摘要：
The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.
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