A predictive CD8+ T cell phenotype for T1DM progression

被引：0
|
作者：
F. Susan Wong
Li Wen
机构：
[1] Division of Infection and Immunity,
[2] Cardiff University School of Medicine,undefined
[3] Cardiff University,undefined
[4] Section of Endocrinology,undefined
[5] Yale School of Medicine,undefined
来源：
Nature Reviews Endocrinology | 2020年 / 16卷
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摘要：
In a cross-sectional study of individuals with type 1 diabetes mellitus, those who were designated to be slow disease progressors had an increased proportion of autoreactive, islet-specific CD8+ T cells expressing an ‘exhausted’ phenotype. By contrast, rapid disease progressors had increased numbers of islet-specific CD8+ T cells with a transitional memory phenotype.
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页码：198 / 199
页数：1
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