A predictive CD8+ T cell phenotype for T1DM progression

被引：0

作者：

F. Susan Wong

Li Wen

机构：

[1] Division of Infection and Immunity,

[2] Cardiff University School of Medicine,undefined

[3] Cardiff University,undefined

[4] Section of Endocrinology,undefined

[5] Yale School of Medicine,undefined

来源：

Nature Reviews Endocrinology | 2020年 / 16卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

In a cross-sectional study of individuals with type 1 diabetes mellitus, those who were designated to be slow disease progressors had an increased proportion of autoreactive, islet-specific CD8+ T cells expressing an ‘exhausted’ phenotype. By contrast, rapid disease progressors had increased numbers of islet-specific CD8+ T cells with a transitional memory phenotype.

引用

页码：198 / 199

页数：1

共 50 条

[21] T Cell Help Amplifies Innate Signals in CD8+ DCs for Optimal CD8+ T Cell Priming
Greyer, Marie
Whitney, Paul G.
Stock, Angus T.
Davey, Gayle M.
Tebartz, Christina
Bachem, Annabell
Mintern, Justine D.
Strugnell, Richard A.
Turner, Stephen J.
Gebhardt, Thomas
O'Keeffe, Meredith
Heath, William R.
Bedoui, Sammy
CELL REPORTS, 2016, 14 (03): : 586 - 597
[22] Upregulation of CD4 on CD8+ T cells:: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells
Sullivan, YB
Landay, AL
Zack, JA
Kitchen, SG
Al-Harthi, L
IMMUNOLOGY, 2001, 103 (03) : 270 - 280
[23] Immunotherapy advance for T1DM
Claire Greenhill
Nature Reviews Endocrinology, 2017, 13 : 564 - 564
[24] Dynamic imaging of chemokine-dependent CD8+ T cell help for CD8+ T cell responses
Stéphanie Hugues
Alix Scholer
Alexandre Boissonnas
Alexander Nussbaum
Christophe Combadière
Sebastian Amigorena
Luc Fetler
Nature Immunology, 2007, 8 : 921 - 930
[25] A Parental History of T2DM Is Frequent and Conveys an Adverse Cardiometabolic Phenotype in T1DM Offspring
Hermans, Michel P.
Ahn, Sylvie A.
Rousseau, Michel F.
DIABETES, 2016, 65 : A364 - A364
[26] T-CELL PROLYMPHOCYTIC LEUKEMIA WITH AN UNUSUAL PHENOTYPE CD4+ CD8+
KLUINNELEMANS, HC
GMELIGMEYLING, FHJ
KOOTTE, AMM
DENOTTOLANDER, GJ
TERMIJTELEN, A
KLUIN, PM
BEVERSTOCK, GC
BRAND, A
CANCER, 1987, 60 (04) : 794 - 803
[27] CD8+ T cell tolerance: It doesn't translate
Block, Katharine E.
Jameson, Stephen C.
IMMUNITY, 2024, 57 (06) : 1184 - 1186
[28] Sphingolipids involved in T1DM
Greenhill, Claire
NATURE REVIEWS ENDOCRINOLOGY, 2018, 14 (07) : 381 - 381
[29] T1DM and the gut microbiome
Jennifer Sargent
Nature Reviews Endocrinology, 2015, 11 (4) : 193 - 193
[30] Insulitic profiles in T1DM
Tim Geach
Nature Reviews Endocrinology, 2016, 12 (4) : 187 - 187

← 1 2 3 4 5 →