Dissolving polymer microneedle patches for influenza vaccination

被引：0

作者：

Sean P Sullivan

Dimitrios G Koutsonanos

Maria del Pilar Martin

Jeong Woo Lee

Vladimir Zarnitsyn

Seong-O Choi

Niren Murthy

Richard W Compans

Ioanna Skountzou

Mark R Prausnitz

机构：

[1] Georgia Institute of Technology,Wallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia Tech

[2] Emory University School of Medicine,Department of Microbiology & Immunology and Emory Vaccine Center

[3] School of Chemical and Biomolecular Engineering,undefined

[4] Georgia Institute of Technology,undefined

来源：

Nature Medicine | 2010年 / 16卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Sullivan and his colleagues describe a novel microneedle patch-based system for vaccine delivery that targets the skin's antigen-presenting cells, providing improved immunogenicity and eliminating the hazards associated with using hypodermic needles. The group demonstrates the feasibility of this approach for influenza prophylaxis, whereby vaccine is encapsulated within microscopic polymeric needles that dissolve in the skin in minutes.

引用

页码：915 / 920

页数：5

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