Dissolving polymer microneedle patches for influenza vaccination

被引：0
|
作者：
Sean P Sullivan
Dimitrios G Koutsonanos
Maria del Pilar Martin
Jeong Woo Lee
Vladimir Zarnitsyn
Seong-O Choi
Niren Murthy
Richard W Compans
Ioanna Skountzou
Mark R Prausnitz
机构：
[1] Georgia Institute of Technology,Wallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia Tech
[2] Emory University School of Medicine,Department of Microbiology & Immunology and Emory Vaccine Center
[3] School of Chemical and Biomolecular Engineering,undefined
[4] Georgia Institute of Technology,undefined
来源：
Nature Medicine | 2010年 / 16卷
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摘要：
Sullivan and his colleagues describe a novel microneedle patch-based system for vaccine delivery that targets the skin's antigen-presenting cells, providing improved immunogenicity and eliminating the hazards associated with using hypodermic needles. The group demonstrates the feasibility of this approach for influenza prophylaxis, whereby vaccine is encapsulated within microscopic polymeric needles that dissolve in the skin in minutes.
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页码：915 / 920
页数：5
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