The critical role of KLF4 in regulating the activation of A1/A2 reactive astrocytes following ischemic stroke

被引:0
|
作者
Cong Wang
Longxuan Li
机构
[1] Ruijin Hospital,Department of Neurology and Institute of Neurology
[2] Shanghai Jiao Tong University School of Medicine,The Graduate School
[3] Ningxia Medical University,undefined
关键词
Cerebral ischemic stroke; Kruppel-like transcription factor 4; Astrocyte; Inflammation;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [31] Bone Marrow Mesenchymal Stem Cell-Derived Exosomal KLF4 Alleviated Ischemic Stroke Through Inhibiting N6-Methyladenosine Modification Level of Drp1 by Targeting lncRNA-ZFAS1
    Qing-Song Wang
    Rong-Jun Xiao
    Jun Peng
    Zheng-Tao Yu
    Jun-Qi Fu
    Ying Xia
    Molecular Neurobiology, 2023, 60 : 3945 - 3962
  • [32] Distinct roles of A1/A2 astrocytes in blood-brain barrier injury following cerebral I/R via the ROCK/NF-κB and STAT3 pathways
    Geng, Zhifeng
    Deng, Guoyi
    Wang, Ziyu
    Xu, Xin
    Yin, Xiaojiao
    Zhang, Sen
    Shao, Jiale
    Wen, Jiyue
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2025, 151
  • [33] ApoE Mimic Peptide COG1410 Reduces Aβ Deposition and Improves Cognitive Function by Inducing the Transformation of A1/A2 Reactive Astrocytes and Increasing the BDNF Concentration in Brain of APP/PS1 Double Transgenic Mice
    Qiao, Yue
    Liu, Hang
    He, Chaoying
    Ma, Ying
    NEUROSCIENCE, 2024, 537 : 116 - 125
  • [34] Lack of a role for CYP1A2 in the activation of 4-aminobiphenyl into DNA-reactive metabolites in mice.
    Clay, CD
    Tsuneoka, Y
    Dalton, TP
    Shertzer, HG
    Miller, ML
    Nebert, DW
    TOXICOLOGICAL SCIENCES, 2003, 72 : 336 - 336
  • [35] Pharmacologic Toll-like receptor 4 inhibition skews toward a favorable A1/A2 astrocytic ratio improving neurocognitive outcomes following traumatic brain injury
    El Baassiri, Mahmoud G.
    Rahal, Simon S.
    Fulton, William B.
    Sodhi, Chhinder P.
    Hackam, David J.
    Nasr, Isam W.
    JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 2023, 95 (03): : 361 - 367
  • [36] Steap4 Plays a Critical Role in Osteoclastogenesis in Vitro by Regulating Cellular Iron/Reactive Oxygen Species (ROS) Levels and cAMP Response Element-binding Protein (CREB) Activation
    Zhou, Jian
    Ye, Shiqiao
    Fujiwara, Toshifumi
    Manolagas, Stavros C.
    Zhao, Haibo
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (42) : 30064 - 30074
  • [37] Downregulation of Aquaporin 4 Expression through Extracellular Signal-regulated Kinases1/2 Activation in Cultured Astrocytes Following Scratch-injury
    SHI Zhong Fang
    ZHAO Wei Jiang
    XU Li Xin
    DONG Li Ping
    YANG Shao Hua
    YUAN Fang
    Biomedical and Environmental Sciences, 2015, 28 (03) : 199 - 205
  • [38] Downregulation of Aquaporin 4 Expression through Extracellular Signal-regulated Kinases1/2 Activation in Cultured Astrocytes Following Scratch-injury
    Shi Zhong Fang
    Zhao Wei Jiang
    Xu Li Xin
    Dong Li Ping
    Yang Shao Hua
    Yuan Fang
    BIOMEDICAL AND ENVIRONMENTAL SCIENCES, 2015, 28 (03) : 199 - 205
  • [39] Reactive Oxygen Species (ROS) Play a Critical Role in the cAMP-Induced Activation of Ras and the Phosphorylation of ERK1/2 in Leydig Cells
    Tai, Ping
    Ascoli, Mario
    MOLECULAR ENDOCRINOLOGY, 2011, 25 (05) : 885 - 893
  • [40] Multiprotein Complex With TRPC (Transient Receptor Potential-Canonical) Channel, PDE1C (Phosphodiesterase 1C), and A2R (Adenosine A2 Receptor) Plays a Critical Role in Regulating Cardiomyocyte cAMP and Survival
    Zhang, Yishuai
    Knight, Walter
    Chen, Si
    Mohan, Amy
    Yan, Chen
    CIRCULATION, 2018, 138 (18) : 1988 - 2002