A phase I safety, pharmacological, and biological study of the farnesyl protein transferase inhibitor, lonafarnib (SCH 663366), in combination with cisplatin and gemcitabine in patients with advanced solid tumors

被引：0
|
作者：
Laura Q. M. Chow
S. Gail Eckhardt
Cindy L. O’Bryant
Mary Kay Schultz
Mark Morrow
Stacy Grolnic
Michele Basche
Lia Gore
机构：
[1] University of Colorado Cancer Center,
[2] The Children’s Hospital,undefined
[3] University of Colorado Health Sciences Center at Fitzsimons,undefined
来源：
Cancer Chemotherapy and Pharmacology | 2008年 / 62卷
关键词：
Lonafarnib; SCH66336; Cisplatin; Gemcitabine; Farnesyltransferase; Phase I; Pharmacokinetics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：631 / 646
页数：15
相关论文
共 50 条
  • [41] A phase I, pharmacokinetic, and biological study of the farnesyltransferase inhibitor tipifarnib in combination with gemcitabine in patients with advanced malignancies
    Patnaik, A
    Eckhardt, SG
    Izbicka, E
    Tolcher, AA
    Hammond, LA
    Takimoto, CH
    Schwartz, G
    McCreery, H
    Goetz, A
    Mori, M
    Terada, K
    Gentner, L
    Rybak, ME
    Richards, H
    Zhang, S
    Rowinsky, EK
    CLINICAL CANCER RESEARCH, 2003, 9 (13) : 4761 - 4771
  • [42] A phase I study of the safety, tolerability and pharmacokinetics of pazopanib (P) in combination with gemcitabine (G) for advanced solid tumors
    Richly, H.
    Rubin, S. D.
    Madi, A.
    Jeffels, M.
    Nokay, B.
    Gibson, D.
    Weller, S.
    Scheulen, M. E.
    Plummer, R.
    EJC SUPPLEMENTS, 2010, 8 (07): : 25 - 25
  • [43] A Phase I Study of GGTI-2418 (Geranylgeranyl Transferase I Inhibitor) in Patients with Advanced Solid Tumors
    Karasic, Thomas B.
    Chiorean, E. Gabriela
    Sebti, Said M.
    O'Dwyer, Peter J.
    TARGETED ONCOLOGY, 2019, 14 (05) : 613 - 618
  • [44] A Phase I Study of GGTI-2418 (Geranylgeranyl Transferase I Inhibitor) in Patients with Advanced Solid Tumors
    Thomas B. Karasic
    E. Gabriela Chiorean
    Said M. Sebti
    Peter J. O’Dwyer
    Targeted Oncology, 2019, 14 : 613 - 618
  • [45] Phase I and pharmacokinetic study of irinotecan in combination with R115777, a farnesyl protein transferase inhibitor
    Sparreboom, A
    Kehrer, DFS
    Mathijssen, RHJ
    Xie, R
    de Jonge, MJA
    de Bruijn, P
    Planting, T
    Eskens, FALM
    Verheij, C
    de Heus, G
    Klaren, A
    Zhang, S
    Verhaeghe, T
    Palmer, PA
    Verweij, J
    BRITISH JOURNAL OF CANCER, 2004, 90 (08) : 1508 - 1515
  • [46] Phase I and pharmacokinetic study of irinotecan in combination with R115777, a farnesyl protein transferase inhibitor
    A Sparreboom
    D F S Kehrer
    R H J Mathijssen
    R Xie
    M J A de Jonge
    P de Bruijn
    A S T Planting
    F A L M Eskens
    C Verheij
    G de Heus
    A Klaren
    S Zhang
    T Verhaeghe
    P A Palmer
    J Verweij
    British Journal of Cancer, 2004, 90 : 1508 - 1515
  • [47] Phase I clinical trial of bortezomib in combination with gemcitabine in patients with advanced solid tumors
    Ryan, David P.
    Appleman, Leonard J.
    Lynch, Thomas
    Supko, Jeffrey G.
    Fidias, Panagiotis
    Clark, Jeffrey W.
    Fishman, Mayer
    Zhu, Andrew X.
    Enzinger, Peter C.
    Kashala, Oscar
    Cusack, James, Jr.
    Eder, Joseph P.
    CANCER, 2006, 107 (10) : 2482 - 2489
  • [48] Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C β-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer
    Rademaker-Lakhai, Jeany M.
    Beerepoot, Laurens V.
    Mehra, Niven
    Radema, Sandra A.
    van Maanen, Rianne
    Vermaat, Joost S.
    Witteveen, Els O.
    Visseren-Grul, Carla M.
    Musib, Luna
    Enas, Nathan
    van Hal, Gertjan
    Beijnen, Jos H.
    Schellens, Jan H. M.
    Voest, Emile E.
    CLINICAL CANCER RESEARCH, 2007, 13 (15) : 4474 - 4481
  • [49] A phase I trial of SCH900776, a selective inhibitor of checkpoint kinase CHK-1, in combination with Gemcitabine in advanced solid tumors
    Daud, A.
    Soon, C.
    Springett, G.
    Mendelson, D.
    Munster, P.
    Goldman, J.
    Strosberg, J.
    Kato, G.
    Horowitz, J.
    Rosen, L.
    EJC SUPPLEMENTS, 2010, 8 (07): : 158 - 158
  • [50] Ongoing phase I study of pemetrexed combined with gemcitabine and cisplatin in patients with locally advanced or metastatic solid tumors
    Boiling, Claus
    Luebbing, Corinna
    Graefe, Tobias
    Fleeth, Jochen
    von Scheel, Jobst
    Luedtke, Frank E.
    Mueller-Hagen, Sigrun
    Depenbrock, Henrik
    Ohnmacht, Ute
    Hanauske, Axel-R
    ANNALS OF ONCOLOGY, 2004, 15 : 104 - 104
12345