Synthesis and biological activity of N-(2-hydroxyethyl)cytisine derivatives

被引：0
|
作者：
D. V. Shishkin
A. R. Shaimuratova
A. N. Lobov
N. Z. Baibulatova
L. V. Spirikhin
M. S. Yunusov
N. S. Makara
N. Zh. Baschenko
V. A. Dokichev
机构：
[1] Russian Academy of Sciences,Institute of Organic Chemistry, Ufa Scientific Center
来源：
Chemistry of Natural Compounds | 2007年 / 43卷
关键词：
cytisine; -(2-hydroxyethyl)cytisine derivatives; reduction; metal hydrides; antiarrhythmic and analgesic activity;
D O I：
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学科分类号：
摘要：
Derivatives of N-(2-hydroxyethyl)cytisine, N-(2-hydroxypropyl)-, N-(2-hydroxy-2-(1-adamantyl)ethyl)-, and N-(2-hydroxy-2-phenylethyl)cytisine, were synthesized by reduction of N-(2-oxopropyl)-, N-(2-oxo-2-(1-adamantyl)ethyl)-and N-(2-oxo-2-phenylethyl)cytisine with metal hydrides. The antiarrhythmic and analgesic activities of the prepared compounds were investigated.
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页码：190 / 196
页数：6
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