Synthesis and biological activity of N-(2-hydroxyethyl)cytisine derivatives

被引：10

作者：

Shishkin, D. V. ^{[1
]}

Shaimuratova, A. R. ^{[1
]}

Lobov, A. N. ^{[1
]}

Baibulatova, N. Z. ^{[1
]}

Spirikhin, L. V. ^{[1
]}

Yunusov, M. S. ^{[1
]}

Makara, N. S. ^{[1
]}

Baschenko, N. Zh. ^{[1
]}

Dokichev, V. A. ^{[1
]}

机构：

[1] Russian Acad Sci, Ufa Sci Ctr, Inst Organ Chem, Ufa 450054, Russia

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2007年 / 43卷 / 02期

关键词：

cytisine; N-(2-hydroxyethyl)cytisine derivatives; reduction; metal hydrides; antiarrhythmic and analgesic activity;

D O I：

10.1007/s10600-007-0076-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Derivatives of N-(2-hydroxyenthyl)cytisine, N-(2-hydroxypropyl)-, N-(2-hydroxy-2-(1-adamantyl)ethyl)-, and N-(2-hydroxy-2-phenylethyl)cystine, were synthesized by reduction of N-(2-oxopropyl)-, N-(2-oxo-2-(1-adamantyl)ethyl)- and N-(2-oxo-2-phenylethyl)cytisine with metal hydrides. The antiarrhythmic and analgesic activities of the prepared compounds were investigated.

引用

页码：190 / 196

页数：7

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