Effects of the histamine H1 receptor antagonist hydroxyzine on hERG K+ channels and cardiac action potential duration

被引：0
|
作者：
Byung Hoon Lee
Seung Ho Lee
Daehyun Chu
Jin Won Hyun
Han Choe
Bok Hee Choi
Su-Hyun Jo
机构：
[1] Institute of Bioscience and Biotechnology,Department of Physiology
[2] Kangwon National University School of Medicine,Department of Radiology
[3] Ilsan Paik Hospital,Department of Pharmacology
[4] Inje University School of Medicine,Department of Physiology
[5] Institute for Medical Sciences,Department of Biochemistry
[6] Chonbuk National University Medical School,undefined
[7] Bio-Medical Institute of Technology,undefined
[8] University of Ulsan College of Medicine,undefined
[9] School of Medicine,undefined
[10] Jeju National University,undefined
来源：
Acta Pharmacologica Sinica | 2011年 / 32卷
关键词：
histamine antagonists; hydroxyzine; cardiomyocytes; hERG channels; K; channel; proarrhythmic effects;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：1128 / 1137
页数：9
相关论文
共 50 条
  • [21] Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine
    Aslanian, R
    Mutahi, MW
    Shih, NY
    Piwinski, JJ
    West, R
    Williams, SM
    She, S
    Wu, RL
    Hey, JA
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (12) : 1959 - 1961
  • [22] A dual antagonist for chemokine CCR3 receptor and histamine H1 receptor
    Suzuki, Keiko
    Morokata, Tatsuaki
    Morihira, Koichiro
    Sato, Ippei
    Takizawa, Satoko
    Kaneko, Masayuki
    Takahashi, Koichiro
    Shimizu, Yasuaki
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2007, 563 (1-3) : 224 - 232
  • [23] Opiate and H1 antagonist effects on histamine induced pruritus and alloknesis
    Heyer, G
    Dotzer, M
    Diepgen, TL
    Handwerker, HO
    PAIN, 1997, 73 (02) : 239 - 243
  • [24] Sleep propensity is essential for the sleep induction of an histamine H1 receptor antagonist
    Huang, Zhi-Li
    Qu, Wei-Min
    Matsumoto, Naomi
    Urade, Yoshihiro
    Hayaishi, Osamu
    NEUROSCIENCE RESEARCH, 2008, 61 : S190 - S190
  • [25] Comparative anticholinergic activity of histamine (H1) receptor antagonist drugs.
    Kovalesky, CA
    Currie, D
    Orzechowski, RF
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2002, 71 (02) : P13 - P13
  • [26] Population pharmacokinetics of epinastine, a histamine H1 receptor antagonist, in adults and children
    Sarashina, A
    Tatami, S
    Yamamura, N
    Tsuda, Y
    Igarashi, T
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2005, 59 (01) : 43 - 53
  • [27] Mutational analysis of the antagonist-binding site of the histamine H1 receptor
    Wieland, K
    Ter Laak, AM
    Smit, MJ
    Kühne, R
    Timmerman, H
    Leurs, R
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (42) : 29994 - 30000
  • [28] Suppression of Osteopontin Functions by Levocetirizine, a Histamine H1 Receptor Antagonist, In Vitro
    Komatsuzaki, Toshimitsu
    Suzaki, Isao
    Hirano, Kojiro
    Kanai, Ken-Ichi
    Asano, Kazuhito
    Suzaki, Harumi
    BIOMED RESEARCH INTERNATIONAL, 2013, 2013
  • [29] 5-lipoxygenase inhibitors with histamine H1 receptor antagonist activity
    Lewis, TA
    Bayless, L
    Eckman, JB
    Ellis, JL
    Grewal, G
    Libertine, L
    Nicolas, JM
    Scannell, RT
    Wels, BF
    Wenberg, K
    Wypij, DM
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (09) : 2265 - 2268
  • [30] Biochemical characterization of desloratadine, a potent antagonist of the human histamine H1 receptor
    Anthes, JC
    Gilchrest, H
    Richard, C
    Eckel, S
    Hesk, D
    West, RE
    Williams, SM
    Greenfeder, S
    Billah, M
    Kreutner, W
    Egan, RW
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 449 (03) : 229 - 237
12345