Bivalent IAP antagonists inhibit TRAF2-bound cIAPs and limit TNF-mediated NF-κB signaling

被引:0
|
作者
Stephen M Condon
机构
[1] TetraLogic Pharmaceuticals Corporation,
[2] 343 Phoenixville Pike,undefined
来源
Cell Death & Disease | 2016年 / 7卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:e2385 / e2385
相关论文
共 50 条
  • [31] The RING domain of TRAF2 inhibits TNFα-induced cell death independent of NF-κB activation
    Zhang, Laiqun
    Blackwell, Ken
    Shi, Zhaohui
    Habelhah, Hasem
    CANCER RESEARCH, 2010, 70
  • [32] TNF-α/NF-κB Signaling in the CNS: Possible Connection to EPHB2
    Paul D. Pozniak
    Martyn K. White
    Kamel Khalili
    Journal of Neuroimmune Pharmacology, 2014, 9 : 133 - 141
  • [33] Negative regulation of constitutive NF-κB and JNK signaling by PKN1-mediated phosphorylation of TRAF1
    Kato, Tomohisa, Jr.
    Gotoh, Yusuke
    Hoffmann, Alexander
    Ono, Yoshitaka
    GENES TO CELLS, 2008, 13 (05) : 509 - 520
  • [34] The inhibitor of apoptosis protein fusion c-IAP2•MALT1 stimulates NF-κB activation independently of TRAF1 AND TRAF2
    Varfolomeev, Eugene
    Wayson, Sarah M.
    Dixit, Vishva M.
    Fairbrother, Wayne J.
    Vucic, Domagoj
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (39) : 29022 - 29029
  • [35] Inhibiting TRAF2-mediated Activation of NF-κB Facilitates Induction of AP-1
    Manna, Sunil K.
    Babajan, Banaganapalli
    Raghavendra, Pongali B.
    Raviprakash, Nune
    Sureshkumar, Chitta
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (15) : 11617 - 11627
  • [36] H-pylori activates NF-κB through a signaling pathway involving IκB kinases, NF-κB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells
    Maeda, S
    Yoshida, H
    Ogura, K
    Mitsuno, Y
    Hirata, Y
    Yamaji, Y
    Akanuma, M
    Shiratori, Y
    Omata, M
    GASTROENTEROLOGY, 2000, 119 (01) : 97 - +
  • [37] Roburic Acid Targets TNF to Inhibit the NF-κB Signaling Pathway and Suppress Human Colorectal Cancer Cell Growth
    Xu, Huanhuan
    Liu, Titi
    Li, Jin
    Chen, Fei
    Xu, Jing
    Hu, Lihong
    Jiang, Li
    Xiang, Zemin
    Wang, Xuanjun
    Sheng, Jun
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [38] Danshensu enhances autophagy and reduces inflammation by downregulating TNF-α to inhibit the NF-κB signaling pathway in ischemic flaps
    Huang, Yingying
    Lai, Yingying
    Chen, Liang
    Fu, Kejian
    Shi, Donghao
    Ma, Xianhui
    Yang, Ningning
    Chen, Xuankuai
    Cheng, Sheng
    Lu, Jingzhou
    Zhang, Xuzi
    Gao, Weiyang
    PHYTOMEDICINE, 2025, 137
  • [39] IKK1/2 protect human cells from TNF-mediated RIPK1-dependent apoptosis in an NF-κB-independent manner
    Slotta, Carsten
    Storm, Jonathan
    Pfisterer, Nina
    Henkel, Elena
    Kleinwaechter, Svenja
    Pieper, Maren
    Ruiz-Perera, Lucia M.
    Greiner, Johannes F. W.
    Kaltschmidt, Barbara
    Kaltschmidt, Christian
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2018, 1865 (08): : 1025 - 1033
  • [40] Encephalomyocarditis Virus 3C Protease Relieves TRAF Family Member-associated NF-κB Activator (TANK) Inhibitory Effect on TRAF6-mediated NF-κB Signaling through Cleavage of TANK
    Huang, Li
    Liu, Qinfang
    Zhang, Lijie
    Zhang, Quan
    Hu, Liang
    Li, Changyao
    Wang, Shengnan
    Li, Jiangnan
    Zhang, Yuanfeng
    Yu, Huibin
    Wang, Yan
    Zhong, Zhaohua
    Xiong, Tao
    Xia, Xueshan
    Wang, Xiaojun
    Yu, Li
    Deng, Guohua
    Cai, Xuehui
    Cui, Shangjin
    Weng, Changjiang
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (46) : 27618 - 27632