Bivalent IAP antagonists inhibit TRAF2-bound cIAPs and limit TNF-mediated NF-κB signaling

被引：0
|
作者：
Stephen M Condon
机构：
[1] TetraLogic Pharmaceuticals Corporation,
[2] 343 Phoenixville Pike,undefined
来源：
Cell Death & Disease | 2016年 / 7卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：e2385 / e2385
相关论文
共 50 条
  • [21] TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-κB pathway by TRAF-binding TNFRs
    Hauer, J
    Püschner, S
    Ramakrishnan, P
    Simon, U
    Bongers, M
    Federle, C
    Engelmann, H
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (08) : 2874 - 2879
  • [22] TNFα- and IKKβ-mediated TANK/I-TRAF phosphorylation:: implications for interaction with NEMO/IKKγ and NF-κB activation
    Bonif, M
    Meuwis, MA
    Close, P
    Benoit, V
    Heyninck, K
    Chapelle, JP
    Bours, V
    Merville, MP
    Piette, J
    Beyaert, R
    Chariot, A
    BIOCHEMICAL JOURNAL, 2006, 394 (593-603) : 593 - 603
  • [23] Cardiac glycosides inhibit TNF-α/NF-κB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor
    Yang, QF
    Huang, W
    Jozwik, C
    Lin, Y
    Glasman, M
    Caohuy, H
    Srivastava, M
    Esposito, D
    Gillette, W
    Hartley, J
    Pollard, HB
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (27) : 9631 - 9636
  • [24] Birinapant, a novel bivalent Smac mimetic drug, is superior to monovalent Smac mimetics in inhibition of NF-kB by targeting TRAF2-bound clAP1 and clAP2.
    Mitsuuchi, Yasuhiro
    Condon, Stephen M.
    Neiman, Eric M.
    Benetatos, Christopher A.
    Seipel, Martin E.
    Kapoor, Gurpreet Singh
    Mufalli, Angeline C.
    Yu, Guangyao
    Maguire, Orla
    Minderman, Hans
    Mckinlay, Mark A.
    Graham, Martin
    Weng, David
    Chunduru, Srinivas
    CANCER RESEARCH, 2013, 73 (08)
  • [25] Caspase-Mediated Cleavage, IAP Binding, and Ubiquitination: Linking Three Mechanisms Crucial for Drosophila NF-κB Signaling
    Paquette, Nicholas
    Broemer, Meike
    Aggarwal, Kamna
    Chen, Li
    Husson, Marie
    Erturk-Hasdemir, Deniz
    Reichhart, Jean-Marc
    Meier, Pascal
    Silverman, Neal
    MOLECULAR CELL, 2010, 37 (02) : 172 - 182
  • [26] CP-25 inhibits the functions of activated human B cells through regulating BAFF-TRAF2-NF-κB and TNF-alpha-TRAF2-NF-κB signaling
    Ling-ling ZHANG
    Feng ZHANG
    Jin-ling SHU
    Ying LI
    Yu-jing WU
    Xian-zheng ZHANG
    Le HAN
    Xiao-yu TANG
    Chen WANG
    Yu TAI
    Qing-tong WANG
    Jing-yu CHEN
    Yan CHANG
    Hua-xun WU
    Wei WEI
    中国药理学与毒理学杂志, 2017, 31 (10) : 982 - 983
  • [27] Mutations which abolish phosphorylation of the TRAF-binding domain of TNF receptor 2 enhance receptor-mediated NF-κB activation
    Ng, PWP
    Jänicke, RU
    Porter, AG
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 244 (03) : 756 - 762
  • [28] YopJ targets TRAF proteins to inhibit TLR-mediated NF-κB, MAPK and IRF3 signal transduction
    Sweet, Charles R.
    Conlon, Joseph
    Golenbock, Douglas T.
    Goguen, Jon
    Silverman, Neal
    CELLULAR MICROBIOLOGY, 2007, 9 (11) : 2700 - 2715
  • [29] c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor α (TNFα)-induced NF-κB activation
    Varfolomeev, Eugene
    Goncharov, Tatiana
    Fedorova, Anna V.
    Dynek, Jasmin N.
    Zobel, Kerry
    Deshayes, Kurt
    Fairbrother, Wayne J.
    Vucic, Domagoj
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (36) : 24295 - 24299
  • [30] TNF-α/NF-κB Signaling in the CNS: Possible Connection to EPHB2
    Pozniak, Paul D.
    White, Martyn K.
    Khalili, Kamel
    JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2014, 9 (02) : 133 - 141
12345