Synthesis and properties of pyrazole carbaldehyde bis(2-hydroxyethyl)-dithioacetal hydrochlorides*

被引：0
|
作者：
L. K. Papernaya
A. A. Shatrova
A. I. Albanov
E. V. Rudyakova
G. G. Levkovskaya
机构：
[1] A. E. Favorsky Irkutsk Institute of Chemistry,
[2] Siberian Branch,undefined
[3] Russian Academy of Sciences,undefined
来源：
Chemistry of Heterocyclic Compounds | 2012年 / 47卷
关键词：
bis(2-hydroxyethyl)dithioacetals; 2-mercaptoethanol; 1,3-oxathiolane; pyrazole carbaldehydes; trimethylchlorosilane; acetalization;
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摘要：
A simple method has been developed for the synthesis of water-soluble pyrazole derivatives, namely 4-[bis(2-hydroxyethylsulfanyl)methyl]pyrazoles hydrochlorides, by the reaction of a series of pyrazole carbaldehydes with 2-mercaptoethanol in the presence of trimethylchlorosilane. When treated with aqueous ammonia solution the pyrazole-4-carbaldehydes bis(2-hydroxyethyl)dithioacetal hydro-chlorides are converted to the 4-[bis(2-hydroxyethylsulfanyl)methyl]pyrazole free bases.
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页码：1395 / 1404
页数：9
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