The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics

被引:0
|
作者
Ishraga E A-Elbasit
Michael Alifrangis
Insaf F Khalil
Ib C Bygbjerg
Emad M Masuadi
Mustafa I Elbashir
Hayder A Giha
机构
[1] University of Khartoum,Malaria Research Centre (MalRC), Department of Biochemistry, Faculty of Medicine
[2] University of Copenhagen,Centre for Medical Parasitology (CMP) at Institute of Medical Microbiology and Immunology and Institute of Public Health
[3] Arabian Gulf University (AGU),Department of Biochemistry, and Department of Family & Community Medicine, Faculty of Medicine and Medical Sciences
来源
关键词
Malaria; Parasite Infection; Single Nucleotide Polymorphism; Falciparum Malaria; Parasite Density;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [41] Genetic mutations in Plasmodium falciparum and Plasmodium vivax dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) in Vanuatu and Solomon Islands prior to the introduction of artemisinin combination therapy
    Karryn J Gresty
    Karen-Ann Gray
    Albino Bobogare
    Lyndes Wini
    George Taleo
    Jeffrey Hii
    Qin Cheng
    Norman C Waters
    Malaria Journal, 13
  • [42] Plasmodium falciparum and Dihydrofolate Reductase I164L Mutations in Africa
    Alker, Alisa P.
    Juliano, Jonathan J.
    Meshnick, Steven R.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (04) : 1722 - 1722
  • [43] SELECTIVE SWEEPS AND GENETIC LINEAGES OF P. FALCIPARUM CHLOROQUINE RESISTANCE GENE, PLASMODIUM FALCIPARUM DIHYDROPTEROATE SYNTHASE AND P. FALCIPARUM DIHYDROFOLATE REDUCTASE GENES IN KENYA
    Nyabute, Marcel
    Juma, Dennis
    Muiruri, Penninah
    Opot, Benjamin
    Okoth, Raphael
    Nginya, Martha
    Mutisya, Jennifer
    Mugambi, Brenda
    Cheruiyot, Agnes
    Chemwor, Gladys
    Yeda, Redemptah
    Okello, Charles
    Akala, Hoseah
    Andagalu, Ben
    Managbanag, Jim Ray
    Kamau, Edwin
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2019, 101 : 102 - 103
  • [44] P-falciparum dihydrofolate reductase and dihydropteroate synthase mutations:: epidemiology and role in clinical resistance to antifolates
    Plowe, CV
    Kublin, JG
    Doumbo, OK
    DRUG RESISTANCE UPDATES, 1998, 1 (06) : 389 - 396
  • [45] Frequencies distribution of dihydrofolate reductase and dihydropteroate synthetase mutant alleles associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum population from Hadhramout Governorate, Yemen
    Omar A. A. Bamaga
    Mohammed A. K. Mahdy
    Yvonne A. L. Lim
    Malaria Journal, 14
  • [46] Amplification of GTP-cyclohydrolase 1 gene in Plasmodium falciparum isolates with the quadruple mutant of dihydrofolate reductase and dihydropteroate synthase genes in Ghana
    Osei, Musah
    Ansah, Felix
    Matrevi, Sena A.
    Asante, Kwaku P.
    Awandare, Gordon A.
    Quashie, Neils B.
    Duah, Nancy O.
    PLOS ONE, 2018, 13 (09):
  • [47] Molecular epidemiology of Plasmodium falciparum antifolate resistance in Vietnam:: genotyping for resistance variants of dihydropteroate synthase and dihydrofolate reductase
    Masimirembwa, CM
    Phuong-dung, N
    Phuc, BQ
    Duc-Dao, L
    Sy, ND
    Sköld, O
    Swedberg, G
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 1999, 12 (03) : 203 - 211
  • [48] Dihydrofolate reductase and dihydropteroate synthase genotypes associated with in vitro resistance of Plasmodium falciparum to pyrimethamine, trimethoprim, sulfadoxine, and sulfamethoxazole
    Khalil, I
    Ronn, AM
    Alifrangis, M
    Gabar, HA
    Satti, GMH
    Bygbjerg, IC
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2003, 68 (05): : 586 - 589
  • [49] Response of Plasmodium falciparum to cotrimoxazole therapy:: Relationship with plasma drug concentrations and dihydrofolate reductase and dihydropteroate synthase genotypes
    Khalil, IF
    Ronn, AM
    Alifrangis, M
    Gabar, HA
    Jelinek, T
    Satti, GMH
    Bygbjerg, IC
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2005, 73 (01): : 174 - 177
  • [50] POINT MUTATIONS IN THE DIHYDROFOLATE-REDUCTASE THYMIDYLATE SYNTHASE GENE AND PYRIMETHAMINE AND CYCLOGUANIL RESISTANCE IN PLASMODIUM-FALCIPARUM
    BASCO, LK
    DEPECOULAS, PE
    WILSON, CM
    LEBRAS, J
    MAZABRAUD, A
    MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1995, 69 (01) : 135 - 138