Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomains

被引：0
|
作者：
Tomoko Wakabayashi
Katleen Craessaerts
Leen Bammens
Mostafa Bentahir
Filip Borgions
Piet Herdewijn
An Staes
Evy Timmerman
Joël Vandekerckhove
Eric Rubinstein
Claude Boucheix
Kris Gevaert
Bart De Strooper
机构：
[1] Center for Human Genetics,Department for molecular and developmental genetics
[2] K.U.Leuven,Department of Biochemistry
[3] VIB,undefined
[4] Flanders Institute for Biotechnology,undefined
[5] Laboratory of Medicinal Chemistry,undefined
[6] K.U.Leuven,undefined
[7] Department of Medical Protein Research,undefined
[8] Ghent University,undefined
[9] Inserm,undefined
[10] U602,undefined
[11] Université Paris 11,undefined
[12] Institut André Lwoff,undefined
来源：
Nature Cell Biology | 2009年 / 11卷
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学科分类号：
摘要：
The γ-secretase complex is responsible for the generation of amyloid β-peptide, the main component of Alzheimer's disease associated plaques. A proteomic analysis yielded secretory pathway components and membrane-associated tetraspannin microdomains as interactors and regulators of the γ-secretase complex.
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页码：1340 / 1346
页数：6
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