Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomains

被引：0
|
作者：
Tomoko Wakabayashi
Katleen Craessaerts
Leen Bammens
Mostafa Bentahir
Filip Borgions
Piet Herdewijn
An Staes
Evy Timmerman
Joël Vandekerckhove
Eric Rubinstein
Claude Boucheix
Kris Gevaert
Bart De Strooper
机构：
[1] Center for Human Genetics,Department for molecular and developmental genetics
[2] K.U.Leuven,Department of Biochemistry
[3] VIB,undefined
[4] Flanders Institute for Biotechnology,undefined
[5] Laboratory of Medicinal Chemistry,undefined
[6] K.U.Leuven,undefined
[7] Department of Medical Protein Research,undefined
[8] Ghent University,undefined
[9] Inserm,undefined
[10] U602,undefined
[11] Université Paris 11,undefined
[12] Institut André Lwoff,undefined
来源：
Nature Cell Biology | 2009年 / 11卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The γ-secretase complex is responsible for the generation of amyloid β-peptide, the main component of Alzheimer's disease associated plaques. A proteomic analysis yielded secretory pathway components and membrane-associated tetraspannin microdomains as interactors and regulators of the γ-secretase complex.
引用
收藏
页码：1340 / 1346
页数：6
相关论文
共 37 条
  • [21] TETRASPANIN-ENRICHED MICRODOMAINS INVOLVEMENT IN HEPATITIS C VIRUS INFECTION: ROLE OF CD151
    Sanz-Comeno, Paloma
    Martin-Vilchez, Samuel
    Rodriguez-Munoz, Yolanda
    Borque, Maria J.
    Trapero-Marugan, Maria
    Garcia-Buey, Luisa
    Lopez-Cabrera, Manuel
    Moreno-Otero, Ricardo
    HEPATOLOGY, 2008, 48 (04) : 759A - 759A
  • [22] Tetraspanin-enriched microdomains involvement in hepatitis C virus infection: Role of CD151
    Sanz-Cameno, P.
    Martin-Vilchez, S.
    Borque, M. J.
    Rodriguez-Munoz, Y.
    Majano, P. L.
    Garcia-Buey, L.
    Trapero-Marugan, M.
    Lopez-Cabrera, M.
    Moreno-Otero, R.
    JOURNAL OF HEPATOLOGY, 2008, 48 : S222 - S223
  • [23] Cholesterol contributes to the organization of tetraspanin-enriched microdomains and to CD81-dependent infection by malaria sporozoites
    Silvie, Olivier
    Charrin, Stephanie
    Billard, Martine
    Franetich, Jean-Francois
    Clark, Krista L.
    van Gemert, Geert-Jan
    Sauerwein, Robert W.
    Dautry, Francois
    Boucheix, Claude
    Mazier, Dominique
    Rubinstein, Eric
    JOURNAL OF CELL SCIENCE, 2006, 119 (10) : 1992 - 2002
  • [24] Mortalin stabilizes CD151-depedent tetraspanin-enriched microdomains and implicates in the progression of hepatocellular carcinoma
    Liu, Li-Xin
    Lu, Jia-Cheng
    Zeng, Hai-Ying
    Cai, Jia-Bin
    Zhang, Peng-Fei
    Guo, Xiao-Jun
    Huang, Xiao-Yong
    Dong, Rui-Zhao
    Zhang, Chi
    Kang, Qiang
    Zou, Hao
    Zhang, Xin-Yu
    Zhang, Lu
    Zhang, Xiao-Wen
    Ke, Ai-Wu
    Shi, Guo-Ming
    JOURNAL OF CANCER, 2019, 10 (25): : 6199 - 6206
  • [25] EWI2 and its relatives in Tetraspanin-enriched membrane domains regulate malignancy
    Ding, Yingjun
    Chen, Junxiong
    Li, Shuping
    Wren, Jonathan D.
    Bajpai, Akhilesh K.
    Wang, Jie
    Tanaka, Takemi
    Rice, Heather C.
    Hays, Franklin A.
    Lu, Lu
    Zhang, Xin A.
    ONCOGENE, 2023, 42 (12) : 861 - 868
  • [26] Gag Induces the Coalescence of Clustered Lipid Rafts and Tetraspanin-Enriched Microdomains at HIV-1 Assembly Sites on the Plasma Membrane
    Hogue, Ian B.
    Grover, Jonathan R.
    Soheilian, Ferri
    Nagashima, Kunio
    Ono, Akira
    JOURNAL OF VIROLOGY, 2011, 85 (19) : 9749 - 9766
  • [27] EWI2 and its relatives in Tetraspanin-enriched membrane domains regulate malignancy
    Yingjun Ding
    Junxiong Chen
    Shuping Li
    Jonathan D. Wren
    Akhilesh K. Bajpai
    Jie Wang
    Takemi Tanaka
    Heather C. Rice
    Franklin A. Hays
    Lu Lu
    Xin A. Zhang
    Oncogene, 2023, 42 : 861 - 868
  • [28] Clathrin- and Caveolin-Independent Entry of Human Papillomavirus Type 16-Involvement of Tetraspanin-Enriched Microdomains (TEMs)
    Spoden, Gilles
    Freitag, Kirsten
    Husmann, Matthias
    Boller, Klaus
    Sapp, Martin
    Lambert, Carsten
    Florin, Luise
    PLOS ONE, 2008, 3 (10):
  • [29] Expression of the palmitoylation-deficient CD151 weakens the association of α3β1 integrin with the tetraspanin-enriched microdomains and affects integrin-dependent signaling
    Berditchevski, F
    Odintsova, E
    Sawada, S
    Gilbert, E
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (40) : 36991 - 37000
  • [30] Syntenin-1 is a new component of tetraspanin-enriched microdomains: Mechanisms and consequences of the interaction of syntenin-1 with CD63
    Latysheva, Nadya
    Muratov, Gairat
    Rajesh, Sundaresan
    Padgett, Matthew
    Hotchin, Neil A.
    Overduin, Michael
    Berditchevski, Fedor
    MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (20) : 7707 - 7718
1234