Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis

被引：0

作者：

Michael A van Es

Jan H Veldink

Christiaan G J Saris

Hylke M Blauw

Paul W J van Vught

Anna Birve

Robin Lemmens

Helenius J Schelhaas

Ewout J N Groen

Mark H B Huisman

Anneke J van der Kooi

Marianne de Visser

Caroline Dahlberg

Karol Estrada

Fernando Rivadeneira

Albert Hofman

Machiel J Zwarts

Perry T C van Doormaal

Dan Rujescu

Eric Strengman

Ina Giegling

Pierandrea Muglia

Barbara Tomik

Agnieszka Slowik

Andre G Uitterlinden

Corinna Hendrich

Stefan Waibel

Thomas Meyer

Albert C Ludolph

Jonathan D Glass

Shaun Purcell

Sven Cichon

Markus M Nöthen

H-Erich Wichmann

Stefan Schreiber

Sita H H M Vermeulen

Lambertus A Kiemeney

John H J Wokke

Simon Cronin

Russell L McLaughlin

Orla Hardiman

Katsumi Fumoto

R Jeroen Pasterkamp

Vincent Meininger

Judith Melki

P Nigel Leigh

Christopher E Shaw

John E Landers

Ammar Al-Chalabi

Robert H Brown

机构：

[1] Rudolf Magnus Institute of Neuroscience,Department of Neurology

[2] University Medical Center Utrecht,Department of Neurology

[3] Institute of Clinical Neuroscience,Department of Neurology/Clinical Neurophysiology

[4] Umeå University Hospital,Department of Neurology

[5] Experimental Neurology,Department of Internal Medicine

[6] University of Leuven,Department of Epidemiology

[7] Vesalius Research Center,Division of Molecular and Clinical Neurobiology, Department of Psychiatry

[8] Flanders Institute for Biotechnology,Department of Medical Genetics and Rudolf Magnus Institute

[9] University Hospital Leuven,Department of Neurology

[10] University of Leuven,Department of Neurology

[11] Donders Institute for Brain,Department of Neurology

[12] Cognition and Behaviour,Department of Neurology

[13] Centre for Neuroscience,Department of Genomics

[14] Radboud University Nijmegen Medical Center,Department of General Internal Medicine

[15] Academic Medical Center,Department of Epidemiology, Department of Human Genetics

[16] Genetics Laboratory,Department of Urology

[17] Erasmus Medical Center Rotterdam,Department of Clinical Neurological Sciences

[18] Erasmus Medical Center Rotterdam,Department of Neurology

[19] Ludwig-Maximilians-University,Department of Neuroscience and Pharmacology

[20] University Medical Center Utrecht,Department of Neurology

[21] Medical Genetics,Department of Human Genetics

[22] GlaxoSmithKline R&D,Department of Clinical Neuroscience

[23] Jagiellonian University,Department of Neurology

[24] University of Ulm,Department of Neurology

[25] Charité University Hospital,undefined

[26] Humboldt-University,undefined

[27] Emory University,undefined

[28] Center for Human Genetics Research,undefined

[29] Massachusetts General Hospital,undefined

[30] Institute of Human Genetics,undefined

[31] University of Bonn,undefined

[32] Life and Brain Center,undefined

[33] University of Bonn,undefined

[34] Institute of Epidemiology,undefined

[35] Helmholtz Zentrum München,undefined

[36] German Research Center for Environmental Health,undefined

[37] Institute of Medical Informatics,undefined

[38] Biometry and Epidemiology,undefined

[39] Chair of Epidemiology,undefined

[40] Ludwig-Maximilians-Universität,undefined

[41] Klinikum Grosshadern,undefined

[42] Institute for Clinical Molecular Biology,undefined

[43] University of Kiel,undefined

[44] University of Kiel,undefined

[45] Biostatistics & HTA,undefined

[46] Radboud University Nijmegen Medical Center,undefined

[47] Radboud University Nijmegen Medical Center,undefined

[48] Comprehensive Cancer Center East,undefined

[49] Royal College of Surgeons in Ireland,undefined

[50] Beaumont Hospital,undefined

来源：

Nature Genetics | 2009年 / 41卷

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学科分类号：

摘要：

Leonard van den Berg, Roel Ophoff and colleagues present a genome-wide association study of sporadic amyotrophic lateral sclerosis. The work uncovers associated SNPs at 9p21.2 and an associated locus at 19p13.3 mapping to the UNC13A gene.

引用

页码：1083 / 1087

页数：4

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