Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2

被引：240

作者：

Yue, Wei-Hua ^{[1
,2
]}

Wang, Hai-Feng ^{[3
,4
]}

Sun, Liang-Dan ^{[5
,6
,7
]}

Tang, Fu-Lei ^{[1
,2
]}

Liu, Zhong-Hua ^{[8
]}

Zhang, Hong-Xing ^{[9
,10
]}

Li, Wen-Qiang ^{[9
,10
]}

Zhang, Yan-Ling ^{[1
,2
]}

Zhang, Yang ^{[1
,2
]}

Ma, Cui-Cui ^{[11
]}

Du, Bo ^{[12
]}

Wang, Li-Fang ^{[1
,2
]}

Ren, Yun-Qing ^{[5
,6
,7
]}

Yang, Yong-Feng ^{[9
,10
]}

Hu, Xiao-Feng ^{[1
,2
]}

Wang, Yi ^{[3
,4
]}

Deng, Wei ^{[13
]}

Tan, Li-Wen ^{[14
]}

Tan, Yun-Long ^{[15
]}

Chen, Qi ^{[16
]}

Xu, Guang-Ming ^{[17
]}

Yang, Gui-Gang ^{[15
]}

Zuo, Xian-bo ^{[5
,6
,7
]}

Yan, Hao ^{[1
,2
]}

Ruan, Yan-Yan ^{[1
,2
]}

Lu, Tian-Lan ^{[1
,2
]}

Han, Xue ^{[14
]}

Ma, Xiao-Hong ^{[13
]}

Wang, Yan ^{[1
,2
]}

Cai, Li-Wei ^{[1
,2
]}

Jin, Chao ^{[11
]}

Zhang, Hong-Yan ^{[1
,2
]}

Yan, Jun ^{[1
,2
]}

Mi, Wei-Feng ^{[1
,2
]}

Yin, Xian-Yong ^{[5
,6
,7
]}

Ma, Wen-Bin ^{[11
]}

Liu, Qi ^{[1
,2
]}

Kang, Lan ^{[1
,2
]}

Sun, Wei ^{[1
,2
]}

Pan, Cheng-Ying ^{[1
,2
]}

Shuang, Mei ^{[1
,2
]}

Yang, Fu-De ^{[15
]}

Wang, Chuan-Yue ^{[16
]}

Yang, Jian-Li ^{[17
]}

Li, Ke-Qing ^{[12
]}

Ma, Xin ^{[16
]}

Li, Ling-Jiang ^{[14
]}

Yu, Xin ^{[1
,2
]}

Li, Qi-Zhai ^{[18
]}

Huang, Xun ^{[8
]}

机构：

[1] Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China

[2] Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China

[3] Chinese Natl Human Genome Ctr Shanghai, Shanghai Minist Sci & Technol China, Key Lab Hlth & Dis Genom, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, State Key Lab Med Genom, Ruijin Hosp, Shanghai 200030, Peoples R China

[5] Anhui Med Univ, Inst Dermatol, Hosp 1, Hefei, Peoples R China

[6] Anhui Med Univ, Dept Dermatol, Hosp 1, Hefei, Peoples R China

[7] Minist Sci & Technol, State Key Lab Dermatol, Hefei, Peoples R China

[8] Chinese Acad Sci, Key Lab Mol & Dev Biol, Inst Genet & Dev Biol, Beijing, Peoples R China

[9] Xinxiang Med Univ, Dept Psychiat, Affiliated Hosp 2, Xinxiang, Peoples R China

[10] Henan Mental Hosp, Henan Key Lab Biol Psychiat, Xinxiang, Peoples R China

[11] Jinzhou Kangning Hosp, Jinzhou, Peoples R China

[12] Hebei Mental Hlth Ctr, Baoding, Peoples R China

[13] Sichuan Univ, Dept Psychiat, W China Hosp, Chengdu 610064, Peoples R China

[14] Cent S Univ, Inst Mental Hlth, Xiangya Hosp 2, Changsha, Peoples R China

[15] Beijing Huilongguan Hosp, Beijing, Peoples R China

[16] Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China

[17] Tianjin Municipal, Tianjin Anding Hosp, Tianjin, Peoples R China

[18] Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China

来源：

NATURE GENETICS | 2011年 / 43卷 / 12期

基金：

对外科技合作项目（国际科技项目）; 中国国家自然科学基金;

关键词：

COMMON VARIANTS; DISORDER; PROTEIN;

D O I：

10.1038/ng.979

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 individuals with schizophrenia and 1,599 healthy controls; validation: 4,027 individuals with schizophrenia and 5,603 healthy controls). We identified two susceptibility loci for schizophrenia at 6p21-p22.1 (rs1233710 in an intron of ZKSCAN4, P-combined = 4.76 x 10(-11), odds ratio (OR) = 0.79; rs1635 in an exon of NKAPL, P-combined = 6.91 x 10(-12), OR = 0.78; rs2142731 in an intron of PGBD1, P-combined = 5.14 x 10(-10), OR = 0.79) and 11p11.2 (rs11038167 near the 5' UTR of TSPAN18, P-combined = 1.09 x 10(-11), OR = 1.29; rs11038172, P-combined = 7.21 x 10(-10), OR = 1.25; rs835784, P-combined = 2.73 x 10(-11), OR = 1.27). These results add to previous evidence of susceptibility loci for schizophrenia at 6p21-p22.1 in the Han Chinese population. We found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain. These findings may lead to new insights into the pathogenesis of schizophrenia.

引用

页码：1228 / U84

页数：5

共 50 条

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