Fetal Mesenchymal Stromal Cells: an Opportunity for Prenatal Cellular Therapy

被引：31

作者：

Sagar R. ^{[1
]}

Walther-Jallow L. ^{[2
]}

David A.L. ^{[1
,3
]}

Götherström C. ^{[2
]}

Westgren M. ^{[2
]}

机构：

[1] Institute for Women’s Health, University College London, 86-96 Chenies Mews, London

[2] Department of Clinical Science, Intervention and Technology, K57, Division of Obstetrics and Gynecology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm

[3] Katholieke Universiteit Leuven, Oude Markt 13, Leuven

来源：

Current Stem Cell Reports | 2018年 / 4卷 / 1期

关键词：

In utero stem cell transplantation; Mesenchymal stromal cells; Prenatal therapy;

D O I：

10.1007/s40778-018-0118-8

中图分类号：

学科分类号：

摘要：

Purpose of Review: The aim of the study is to provide an overview on the possibility of treating congenital disorders prenatally with mesenchymal stromal cells (MSCs). Recent Findings: MSCs have multilineage potential and a low immunogenic profile and are immunomodulatory and more easy to expand in culture. Their ability to migrate, engraft and differentiate, or act via a paracrine effect on target tissues makes MSCs candidates for clinical therapies. Fetal and extra-fetal MSCs offer higher therapeutic potential compared to MSCs derived from adult sources. Summary: MSCs may be safely transplanted prenatally via ultrasound-guided injection into the umbilical cord. Due to these characteristics, fetal MSCs are of great interest in the field of in utero stem cell transplantation for treatment of congenital disease. © 2018, The Author(s).

引用

页码：61 / 68

页数：7

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