Fetal Mesenchymal Stromal Cells: an Opportunity for Prenatal Cellular Therapy

被引：31
|
作者：
Sagar R. [1 ]
Walther-Jallow L. [2 ]
David A.L. [1 ,3 ]
Götherström C. [2 ]
Westgren M. [2 ]
机构：
[1] Institute for Women’s Health, University College London, 86-96 Chenies Mews, London
[2] Department of Clinical Science, Intervention and Technology, K57, Division of Obstetrics and Gynecology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm
[3] Katholieke Universiteit Leuven, Oude Markt 13, Leuven
来源：
Current Stem Cell Reports | 2018年 / 4卷 / 1期
关键词：
In utero stem cell transplantation; Mesenchymal stromal cells; Prenatal therapy;
D O I：
10.1007/s40778-018-0118-8
中图分类号：
学科分类号：
摘要：
Purpose of Review: The aim of the study is to provide an overview on the possibility of treating congenital disorders prenatally with mesenchymal stromal cells (MSCs). Recent Findings: MSCs have multilineage potential and a low immunogenic profile and are immunomodulatory and more easy to expand in culture. Their ability to migrate, engraft and differentiate, or act via a paracrine effect on target tissues makes MSCs candidates for clinical therapies. Fetal and extra-fetal MSCs offer higher therapeutic potential compared to MSCs derived from adult sources. Summary: MSCs may be safely transplanted prenatally via ultrasound-guided injection into the umbilical cord. Due to these characteristics, fetal MSCs are of great interest in the field of in utero stem cell transplantation for treatment of congenital disease. © 2018, The Author(s).
引用
收藏
页码：61 / 68
页数：7
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