Immunosignatures associated with TP53 status and co-mutations classify prognostically head and neck cancer patients

被引:0
|
作者
Andrea Sacconi
Paola Muti
Claudio Pulito
Giulia Urbani
Matteo Allegretti
Raul Pellini
Nikolay Mehterov
Uri Ben-David
Sabrina Strano
Paolo Bossi
Giovanni Blandino
机构
[1] Clinical Trial Center,Department of Biomedical
[2] Biostatistics and Bioinformatics,Translational Oncology Research Unit
[3] IRCCS Regina Elena National Cancer Institute,Department of Medical Biology
[4] Surgical Science and Oral Health,Research Institute
[5] Milan University,Department of Human Molecular Genetics and Biochemistry
[6] Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico,Department of Biomedical Sciences
[7] Maxillo-Facial Surgery and Dental Unit,undefined
[8] IRCCS Regina Elena National Cancer Institute,undefined
[9] Otolaryngology Head and Neck Surgery Unit,undefined
[10] IRCCS Regina Elena National Cancer Institute,undefined
[11] Medical University-Plovdiv,undefined
[12] Medical University-Plovdiv,undefined
[13] Faculty of Medicine,undefined
[14] Tel Aviv University,undefined
[15] SAFU Unit,undefined
[16] IRCCS Regina Elena National Cancer Institute,undefined
[17] Humanitas University,undefined
[18] IRCCS Humanitas Research Hospital,undefined
来源
关键词
HNSCC; Immunotherapy; Immune checkpoint inhibitor; p53; PDL1; c-MYC; PI3K;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [41] Co-mutations of KRAS/BRAF and TP53 or the high tumor mutation burden to predict survival in patients with biliary tract carcinoma.
    Guo, Lingling
    Kou, Xiaoxia
    Song, Panpan
    Zhang, Xiaoyu
    Zhang, Hongjuan
    Qiu, Jinrong
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [42] Mutations in exon 8 of TP53 are associated with shorter survival in patients with advanced lung cancer
    Liu, Yutao
    Xu, Fang
    Wang, Yubo
    Wu, Qingchen
    Wang, Buhai
    Yao, Yanwen
    Zhang, Yu
    Han-Zhang, Han
    Ye, Junyi
    Zhang, Lu
    Mao, Xinru
    Zhang, Zhe
    Liu, Jing
    Zhu, Liangjun
    Guo, Renhua
    ONCOLOGY LETTERS, 2019, 18 (03) : 3159 - 3169
  • [43] TP53 Mutations as a Driver of Metastasis Signaling in Advanced Cancer Patients
    Pandey, Ritu
    Johnson, Nathan
    Cooke, Laurence
    Johnson, Benny
    Chen, Yuliang
    Pandey, Manjari
    Chandler, Jason
    Mahadevan, Daruka
    CANCERS, 2021, 13 (04) : 1 - 21
  • [44] KRAS, BRAF and TP53 mutations in Romanian colorectal cancer patients
    Murarasu, Daniela
    Puiu, Liliana
    Mihalcea, Corina
    Cinca, Sabin
    Simion, Laurentiu
    JOURNAL OF BIOTECHNOLOGY, 2016, 231 : S92 - S92
  • [45] Heterogeneity in the clinical phenotype of TP53 mutations in breast cancer patients
    J Alsner
    M Yilmaz
    P Guldberg
    LL Hansen
    J Overgaard
    Breast Cancer Research, 2 (Suppl 1)
  • [46] Heterogeneity in the clinical phenotype of TP53 mutations in breast cancer patients
    Alsner, J
    Yilmaz, M
    Guldberg, P
    Hansen, LL
    Overgaard, J
    CLINICAL CANCER RESEARCH, 2000, 6 (10) : 3923 - 3931
  • [47] Prognostic Effect of TP53 and PKD Co-Mutations in Patients with Resected Epidermal Growth Factor Receptor-Mutated Lung Adenocarcinoma
    Liu, Di-Han
    Zhao, Ze-Rui
    Lin, Yao-Bin
    Zhou, Wen-Jie
    Hou, Jing-Yu
    Ye, Zheng-Hao
    Long, Hao
    ANNALS OF SURGICAL ONCOLOGY, 2019, 26 (06) : 1934 - 1941
  • [48] Prognostic Effect of TP53 and PKD Co-Mutations in Patients with Resected Epidermal Growth Factor Receptor-Mutated Lung Adenocarcinoma
    Di-Han Liu
    Ze-Rui Zhao
    Yao-Bin Lin
    Wen-Jie Zhou
    Jing-Yu Hou
    Zheng-Hao Ye
    Hao Long
    Annals of Surgical Oncology, 2019, 26 : 1934 - 1941
  • [49] Associations of TP53 mutations, codon 72 polymorphism and human papillomavirus in head and neck squamous cell carcinoma patients
    Shi, Qi
    Xiao, Kang
    Wei, Wei
    Zhang, Bao-Yun
    Chen, Cao
    Xu, Yin
    Chen, Li-Na
    Song, Yun-Tao
    Ma, Xiao
    Zhang, Nai-Song
    Dong, Xiao-Ping
    ONCOLOGY REPORTS, 2013, 30 (06) : 2811 - 2819
  • [50] Co-occurrence of MYC amplification and TP53 mutations in human cancer
    Ulz, Peter
    Heitzer, Ellen
    Speicher, Michael R.
    NATURE GENETICS, 2016, 48 (02) : 104 - 106