Immunosignatures associated with TP53 status and co-mutations classify prognostically head and neck cancer patients

被引:0
|
作者
Andrea Sacconi
Paola Muti
Claudio Pulito
Giulia Urbani
Matteo Allegretti
Raul Pellini
Nikolay Mehterov
Uri Ben-David
Sabrina Strano
Paolo Bossi
Giovanni Blandino
机构
[1] Clinical Trial Center,Department of Biomedical
[2] Biostatistics and Bioinformatics,Translational Oncology Research Unit
[3] IRCCS Regina Elena National Cancer Institute,Department of Medical Biology
[4] Surgical Science and Oral Health,Research Institute
[5] Milan University,Department of Human Molecular Genetics and Biochemistry
[6] Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico,Department of Biomedical Sciences
[7] Maxillo-Facial Surgery and Dental Unit,undefined
[8] IRCCS Regina Elena National Cancer Institute,undefined
[9] Otolaryngology Head and Neck Surgery Unit,undefined
[10] IRCCS Regina Elena National Cancer Institute,undefined
[11] Medical University-Plovdiv,undefined
[12] Medical University-Plovdiv,undefined
[13] Faculty of Medicine,undefined
[14] Tel Aviv University,undefined
[15] SAFU Unit,undefined
[16] IRCCS Regina Elena National Cancer Institute,undefined
[17] Humanitas University,undefined
[18] IRCCS Humanitas Research Hospital,undefined
来源
关键词
HNSCC; Immunotherapy; Immune checkpoint inhibitor; p53; PDL1; c-MYC; PI3K;
D O I
暂无
中图分类号
学科分类号
摘要
引用
下载
收藏
相关论文
共 50 条
  • [21] TP53 mutations are associated with a particular pattern of genomic imbalances in head and neck squamous cell carcinoma
    Smeets, Serge J.
    Braakhuis, Boudewijn J. M.
    Ylstra, Bauke
    Leemans, C. Rene
    Brakenhoff, Ruud H.
    CELLULAR ONCOLOGY, 2007, 29 (02) : 160 - 160
  • [22] TP53 mutations are associated with a particular pattern of genomic imbalances in head and neck squamous cell carcinoma
    Smeets, S.
    Braakhuis, B.
    Leemans, C. R.
    Brakenhoff, R.
    ORAL ONCOLOGY, 2007, : 196 - 196
  • [23] The status of MGMT methylation and TP53 mutations in patients with glioblastoma
    Jesionek-Kupnicka, Dorota
    Zawlik, Izabela
    Jesien-Lewandowicz, Emilia
    Szybka, Malgorzata
    Kulczycka, Dominika
    Kusinska, Renata
    Kordek, Radzislaw
    VIRCHOWS ARCHIV, 2008, 452 : S153 - S154
  • [24] The status of MGMT methylation and TP53 mutations in patients with glioblastoma
    Jesionek-Kupnicka, Dorota
    Zawlik, Izabela
    Jesien-Lewandowicz, Emilia
    Szybka, Malgorzata
    Kulczycka, Dominika
    Kusinska, Reneta
    Pasz-Walczak, Grazyna
    Kordek, Radzislaw
    VIRCHOWS ARCHIV, 2007, 451 (02) : 240 - 240
  • [25] TP53 DNA contact mutations are selectively associated with allelic loss and have a strong clinical impact in head and neck cancer
    Ralf Erber
    Christian Conradt
    Nils Homann
    Christel Enders
    Martin Finckh
    Andreas Dietz
    Hagen Weidauer
    Franz X Bosch
    Oncogene, 1998, 16 : 1671 - 1679
  • [26] Characteristics and prognosis of rrDLBCL with TP53 mutations and a high-risk subgroup represented by the co-mutations of DDX3X-TP53
    Gao, Fan
    Hu, Kai
    Zheng, Peihao
    Shi, Hui
    Ke, Xiaoyan
    CANCER MEDICINE, 2023, 12 (09): : 10267 - 10279
  • [27] TP53 DNA contact mutations are selectively associated with allelic loss and have a strong clinical impact in head and neck cancer
    Erber, R
    Conradt, C
    Homann, N
    Enders, C
    Finckh, M
    Dietz, A
    Weidauer, H
    Bosch, FX
    ONCOGENE, 1998, 16 (13) : 1671 - 1679
  • [28] Identification of genetic signatures associated with TP53 status in patients with bladder cancer
    Sanchez-Carbayo, M
    Lu, ML
    Socci, N
    Behrendt, N
    Li, WT
    Cordon-Cardo, C
    JOURNAL OF UROLOGY, 2005, 173 (04): : 209 - 210
  • [29] Prognostic Significance of Truncating TP53 Mutations in Head and Neck Squamous Cell Carcinoma
    Lindenbergh-van der Plas, Marlon
    Brakenhoff, Ruud H.
    Kuik, Dirk J.
    Buijze, Marijke
    Bloemena, Elisabeth
    Snijders, Peter J. F.
    Leemans, C. Rene
    Braakhuis, Boudewijn J. M.
    CLINICAL CANCER RESEARCH, 2011, 17 (11) : 3733 - 3741
  • [30] TP53 gene mutations in plasma DNA of cancer patients
    Silva, JM
    Gonzalez, R
    Dominguez, G
    Garcia, JM
    España, P
    Bonilla, F
    GENES CHROMOSOMES & CANCER, 1999, 24 (02): : 160 - 161