Guadinomines, Type III Secretion System Inhibitors, Produced by Streptomyces sp. K01-0509II. Physico-chemical Properties and Structure Elucidation

被引：0
|
作者：
Masato Iwatsuki
Ryuji Uchida
Hitomi Yoshijima
Hideaki Ui
Kazuro Shiomi
Yong-Pil Kim
Tomoyasu Hirose
Toshiaki Sunazuka
Akio Abe
Hiroshi Tomoda
Satoshi Ōmura
机构：
[1] The Kitasato Institute,School of Pharmacy
[2] Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences,undefined
[3] Kitasato University,undefined
[4] Kitasato University,undefined
来源：
The Journal of Antibiotics | 2008年 / 61卷
关键词：
guadinomines; Type III secretion system; sp. K01-0509; EPEC;
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学科分类号：
摘要：
The structures of guadinomines, new inhibitors of a bacterial Type III secretion system produced by Streptomyces sp. K01-0509, were elucidated by spectroscopic studies including various NMR experiments. Guadinomines A, B, C1, C2 and D consist of a carbamoylated cyclic guanidinyl moiety, an alkyl chain moiety and an L-Ala-L-Val moiety in common, while guadinomic acid is a smaller molecule consisting of a carbamoylated cyclic guanidinyl moiety and a hydroxyl hexanoate moiety.
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页码：230 / 236
页数：6
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