Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp -: II.: Physico-chemical properties and structure elucidation

被引：11
|
作者：
Murakami, R
Tomikawa, T
Shin-Ya, K
Shinozaki, J
Kajiura, T
Seto, H
Hayakawa, Y [1 ]
机构：
[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan
[2] Ajinomoto Co Inc, Pharmaceut Res Labs, Kawasaki, Kanagawa 2108681, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2001年 / 54卷 / 09期
关键词：
D O I：
10.7164/antibiotics.54.714
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The structure of ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. AJ9571, was elucidated to be as shown in Fig. 1 by NMR and degradation studies. Ammocidin consists of a 20-membered macrolide ring and three deoxy sugars identified as 6-deoxy-L-glucose, D-digitoxose and D-olivomycose.
引用
收藏
页码：714 / 717
页数：4
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