Role of the promyelocytic leukaemia protein in cell death regulation

被引：0
|
作者：
P Salomoni
M Dvorkina
D Michod
机构：
[1] Samantha Dickson Brain Cancer Unit,
[2] UCL Cancer Institute,undefined
来源：
Cell Death & Disease | 2012年 / 3卷
关键词：
Snail; HNF4; miRs-200; miR-34a; stemness;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The promyelocytic leukaemia gene PML was originally identified at the t(15;17) translocation of acute promyelocytic leukaemia, which generates the oncogene PML-retinoic acid receptor α. PML epitomises a subnuclear structure called PML nuclear body. Current models propose that PML through its scaffold properties is able to control cell growth and survival at many different levels. Here we discuss the current literature and propose new avenues for investigation.
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页码：e247 / e247
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