Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis

被引：0
|
作者：
Xinhua Yu
Saleh M Ibrahim
机构：
[1] The Medical College of Xiamen University,Laboratory of Autoimmunity
[2] Xiamen University,Section of Immunoregulation
[3] Research center Borstel,Department of Dermatology
[4] University of Lübeck,undefined
来源：
Arthritis Research & Therapy | / 13卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Th17 cells are thought to play a pathogenic role in various autoimmune diseases. Cytokines secreted by Th17 cells like IL-17, IL-17F and IL-22 have the capacity to mediate a massive inflammatory response. These proinflammatroy cytokines are likely to mediate the pathogenic potential of Th17 cells. Recent evidence suggests a role for Th17 cells in the breach of immune tolerance. This might shed some new light on the pathogenic role of Th17 cells in autoimmunity.
引用
收藏
相关论文
共 50 条
  • [31] Th17 and Th22 cells in psoriatic arthritis and psoriasis
    Helen Benham
    Paul Norris
    Jane Goodall
    Mihir D Wechalekar
    Oliver FitzGerald
    Agnes Szentpetery
    Malcolm Smith
    Ranjeny Thomas
    Hill Gaston
    Arthritis Research & Therapy, 15
  • [32] Th17 and Th22 cells in psoriasis and psoriatic arthritis
    Benham, H. J.
    Goodall, J. C.
    Gaston, J. S. H.
    IMMUNOLOGY, 2010, 131 : 57 - 57
  • [33] TH17 AND TH22 CELLS IN PSORIASIS AND PSORIATIC ARTHRITIS
    Benham, H.
    Goodall, J.
    Gaston, H.
    INTERNAL MEDICINE JOURNAL, 2011, 41 : 5 - 5
  • [34] Role of Th17 and Treg cells in septic arthritis and the impact of the Th17/Treg -derived cytokines in the pathogenesis of S. aureus induced septic arthritis in mice
    Dey, Ipsita
    Bishayi, Biswadev
    MICROBIAL PATHOGENESIS, 2017, 113 : 248 - 264
  • [35] The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation
    Annunziato, Francesco
    Cosmi, Lorenzo
    Liotta, Francesco
    Maggi, Enrico
    Romagnani, Sergio
    INTERNATIONAL IMMUNOLOGY, 2008, 20 (11) : 1361 - 1368
  • [36] Role of Osteopontin in Synovial Th17 Differentiation in Rheumatoid Arthritis
    Chen, Guangjie
    Zhang, Xin
    Li, Runsheng
    Fang, Lei
    Niu, Xiaoyin
    Zheng, Yingxia
    He, Dongyi
    Xu, Rong
    Zhang, Jingwu Z.
    ARTHRITIS AND RHEUMATISM, 2010, 62 (10): : 2900 - 2908
  • [37] The Role of Flavonoids in Inhibiting Th17 Responses in Inflammatory Arthritis
    Kelepouri, Dimitra
    Mavropoulos, Athanasios
    Bogdanos, Dimitrios P.
    Sakkas, Lazaros I.
    JOURNAL OF IMMUNOLOGY RESEARCH, 2018, 2018
  • [38] The impact of Th17 cells on transplant rejection and the induction of tolerance
    Heidt, Sebastiaan
    San, David
    Chadha, Radhika
    Wood, Kathryn J.
    CURRENT OPINION IN ORGAN TRANSPLANTATION, 2010, 15 (04) : 456 - 461
  • [39] Th17 cells in rheumatoid arthritis and systemic lupus erythematosus
    Pernis, A. B.
    JOURNAL OF INTERNAL MEDICINE, 2009, 265 (06) : 644 - 652
  • [40] TH17 CELLS ARE ENRICHED IN RHEUMATOID ARTHRITIS SYNOVIAL FLUID
    Chowdhury, Kaustav
    Mitra, Dipendra Kumar
    Kumar, Uma
    Kanga, Uma
    INTERNAL MEDICINE JOURNAL, 2012, 42 : 7 - 7
12345