Putative role of epithelial sodium channels (ENaC)in the afferent limb of cardio renal reflexes in rats

被引:0
|
作者
Tilmann Ditting
Peter Linz
Karl F. Hilgers
Oliver Jung
Helmut Geiger
Roland Veelken
机构
[1] J. W. Goethe-University,Department of Nephrology
[2] Friedrich-Alexander-University,Department of Nephrology
来源
Basic Research in Cardiology | 2003年 / 98卷
关键词
Cardiac sensory afferents; mechanosensitive ion channel; conduction velocity; rat;
D O I
暂无
中图分类号
学科分类号
摘要
Recent studies suggest a role of ion channels of the DEG/ENaC family for mechanosensation in different species and in baroreceptor reflex control in rats. We tested the hypothesis that ENaC within the cardiac sensory network are mandatory for mechanosensation. Experiments were performed in male Sprague-Dawley rats, isolated nodose ganglion cells with cardiac afferents and isolated vagus nerves.
引用
收藏
页码:388 / 400
页数:12
相关论文
共 50 条
  • [31] REGULATION OF RENAL EPITHELIAL SODIUM-CHANNELS
    DUCHATELLE, P
    OHARA, A
    LING, BN
    KEMENDY, AE
    KOKKO, KE
    MATSUMOTO, PS
    EATON, DC
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 1992, 114 (1-2) : 27 - 34
  • [32] LUMINAL PROTEOLYTIC ACTIVATION OF THE COLLECTING DUCT EPITHELIAL SODIUM CHANNEL (ENAC) AND ITS POTENTIAL ROLE IN RENAL SODIUM REABSORPTION IN VIVO
    Jacquillet, Gregory
    Unwin, Robert J.
    Chichger, Havovi
    Shirley, David G.
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2012, 27 : 94 - 94
  • [33] Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC)
    Loffing, Johannes
    Korbmacher, Christoph
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2009, 458 (01): : 111 - 135
  • [34] Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC)
    Johannes Loffing
    Christoph Korbmacher
    Pflügers Archiv - European Journal of Physiology, 2009, 458 : 111 - 135
  • [35] Hyperuricemia induces hypertension through activation of renal epithelial sodium channel (ENaC)
    Xu, Weifeng
    Huang, Yujie
    Li, Lei
    Sun, Zhen
    Shen, Yachen
    Xing, Jing
    Li, Min
    Su, Dongming
    Liang, Xiubin
    METABOLISM-CLINICAL AND EXPERIMENTAL, 2016, 65 (03): : 73 - 83
  • [36] Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels
    Diakov, Alexei
    Bera, Katarzyna
    Mokrushina, Marianna
    Krueger, Bettina
    Korbmacher, Christoph
    JOURNAL OF PHYSIOLOGY-LONDON, 2008, 586 (19): : 4587 - 4608
  • [37] Molecular identification of epithelial sodium channels (ENaC) in distal convoluted tubule cells.
    Gesek, FA
    Kaltreider, RC
    White, KE
    Friedman, PA
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1996, 7 (09): : A0163 - A0163
  • [38] Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways
    Enuka, Yehoshua
    Hanukoglu, Israel
    Edelheit, Oded
    Vaknine, Hananya
    Hanukoglu, Aaron
    HISTOCHEMISTRY AND CELL BIOLOGY, 2012, 137 (03) : 339 - 353
  • [39] Epithelial sodium channel (ENaC) plasma membrane turnover is modified in channels containing δ subunits
    Alvarez de la Rosa, Diego
    Luise Wesch, Diana
    Miranda, Pablo
    Giraldez, Teresa
    FASEB JOURNAL, 2012, 26
  • [40] Diversity of channels generated by different combinations of epithelial sodium channel (ENaC) subunits.
    McNicholas, CM
    Canessa, C
    BIOPHYSICAL JOURNAL, 1997, 72 (02) : WP122 - WP122