Putative role of epithelial sodium channels (ENaC)in the afferent limb of cardio renal reflexes in rats

被引:0
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作者
Tilmann Ditting
Peter Linz
Karl F. Hilgers
Oliver Jung
Helmut Geiger
Roland Veelken
机构
[1] J. W. Goethe-University,Department of Nephrology
[2] Friedrich-Alexander-University,Department of Nephrology
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关键词
Cardiac sensory afferents; mechanosensitive ion channel; conduction velocity; rat;
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摘要
Recent studies suggest a role of ion channels of the DEG/ENaC family for mechanosensation in different species and in baroreceptor reflex control in rats. We tested the hypothesis that ENaC within the cardiac sensory network are mandatory for mechanosensation. Experiments were performed in male Sprague-Dawley rats, isolated nodose ganglion cells with cardiac afferents and isolated vagus nerves.
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页码:388 / 400
页数:12
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