RNA-modifying enzymes and their function in a chromatin context

被引：0
|
作者：
Konstantinos Tzelepis
Oliver Rausch
Tony Kouzarides
机构：
[1] University of Cambridge,The Gurdon Institute and Department of Pathology
[2] Storm Therapeutics Ltd,undefined
[3] Babraham Research Campus,undefined
来源：
Nature Structural & Molecular Biology | 2019年 / 26卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Exciting research has connected specific RNA modifications to chromatin, providing evidence for co-transcriptional deposition and function in gene regulation. Here we review insights gained from studying the co-transcriptional roles of RNA modifications, and their influence in normal and disease contexts. We also discuss how the availability of novel technical approaches could raise the translational potential of targeting RNA-modifying enzymes for the treatment of disease.
引用
收藏
页码：858 / 862
页数：4
相关论文
共 50 条
  • [31] Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs - Implications for the molecular pathogenesis of human mitochondrial diseases
    Umeda, N
    Suzuki, T
    Yukawa, M
    Ohya, Y
    Shindo, H
    Watanabe, K
    Suzuki, T
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (02) : 1613 - 1624
  • [32] An RNA-modifying enzyme that governs both the codon and amino acid specificities of isoleucine tRNA
    Soma, A
    Ikeuchi, Y
    Kanemasa, S
    Kobayashi, K
    Ogasawara, N
    Ote, T
    Kato, J
    Watanabe, K
    Sekine, Y
    Suzuki, T
    MOLECULAR CELL, 2003, 12 (03) : 689 - 698
  • [33] ENZYMES FOR MODIFYING AND LABELING DNA AND RNA
    COBIANCHI, F
    WILSON, SH
    METHODS IN ENZYMOLOGY, 1987, 152 : 94 - 110
  • [34] RNA modifying enzymes in health and disease
    Gilbert, Wendy
    Draycott, Austin
    Wang, Matthew
    Escobar-Hoyos, Luisa
    BIOPHYSICAL JOURNAL, 2023, 122 (03) : 27A - 27A
  • [35] Recruitment and function of chromatin modifying complexes
    Workman, JL
    Carrozza, M
    Howe, L
    Hassan, A
    Neely, K
    Prochasson, P
    Galasinski, S
    Brown, C
    FASEB JOURNAL, 2002, 16 (04): : A363 - A363
  • [36] Chromatin-Modifying Enzymes in T Cell Development
    Shapiro, Michael J.
    Shapiro, Virginia Smith
    ANNUAL REVIEW OF IMMUNOLOGY, VOL 38, 2020, 38 : 397 - 419
  • [37] Probing Chromatin-modifying Enzymes with Chemical Tools
    Fischle, Wolfgang
    Schwarzer, Dirk
    ACS CHEMICAL BIOLOGY, 2016, 11 (03) : 689 - 705
  • [38] CAPILLARY ENZYMOPHORESIS OF NUCLEIC-ACID FRAGMENTS USING COUPLED CAPILLARY ELECTROPHORESIS AND CAPILLARY ENZYME MICROREACTORS HAVING SURFACE-IMMOBILIZED RNA-MODIFYING ENZYMES
    MECHREF, Y
    ELRASSI, Z
    ELECTROPHORESIS, 1995, 16 (11) : 2164 - 2171
  • [39] FACTOR IN SERUM AND AMNIOTIC-FLUID IS A SUBSTRATE FOR THE TRANSFER RNA-MODIFYING ENZYME TRANSFER RNA-GUANINE TRANSFERASE
    KATZE, JR
    FARKAS, WR
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (07) : 3271 - 3275
  • [40] Histone modifying and chromatin remodelling enzymes in cancer and dysplastic syndromes
    Gibbons, RJ
    HUMAN MOLECULAR GENETICS, 2005, 14 : R85 - R92
12345