RNA-modifying enzymes and their function in a chromatin context

被引：0
|
作者：
Konstantinos Tzelepis
Oliver Rausch
Tony Kouzarides
机构：
[1] University of Cambridge,The Gurdon Institute and Department of Pathology
[2] Storm Therapeutics Ltd,undefined
[3] Babraham Research Campus,undefined
来源：
Nature Structural & Molecular Biology | 2019年 / 26卷
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学科分类号：
摘要：
Exciting research has connected specific RNA modifications to chromatin, providing evidence for co-transcriptional deposition and function in gene regulation. Here we review insights gained from studying the co-transcriptional roles of RNA modifications, and their influence in normal and disease contexts. We also discuss how the availability of novel technical approaches could raise the translational potential of targeting RNA-modifying enzymes for the treatment of disease.
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页码：858 / 862
页数：4
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