The Relationship Between DOT1L, Histone H3 Methylation, and Genome Stability in Cancer

被引:0
|
作者
Brent J. Guppy
Lucile M-P. Jeusset
Kirk J. McManus
机构
[1] University of Manitoba,Department of Biochemistry & Medical Genetics
[2] CancerCare Manitoba,Research Institute in Oncology and Hematology
关键词
DOT1L; H3K79me1; H3K79me2; H3K79me3; Genome stability; Cancer;
D O I
10.1007/s40610-017-0051-0
中图分类号
学科分类号
摘要
引用
收藏
页码:18 / 27
页数:9
相关论文
共 50 条
  • [31] Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding
    Robertson, A. Gordon
    Bilenky, Mikhail
    Tam, Angela
    Zhao, Yongjun
    Zeng, Thomas
    Thiessen, Nina
    Cezard, Timothee
    Fejes, Anthony P.
    Wederell, Elizabeth D.
    Cullum, Rebecca
    Euskirchen, Ghia
    Krzywinski, Martin
    Birol, Inanc
    Snyder, Michael
    Hoodless, Pamela A.
    Hirst, Martin
    Marra, Marco A.
    Jones, Steven J. M.
    GENOME RESEARCH, 2008, 18 (12) : 1906 - 1917
  • [32] Hesperetin promotes DOT1L degradation and reduces histone H3K79 methylation to inhibit gastric cancer metastasis (vol 84,153499,2021)
    Wang, Si-Wei
    Sheng, Hao
    Zheng, Fang
    Zhang, Feng
    PHYTOMEDICINE, 2025, 136
  • [33] DOT1L is a human chromosome stability gene
    Guppy, Brent
    McManus, Kirk
    CANCER RESEARCH, 2015, 75
  • [34] The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle
    Kim, Wootae
    Choi, Minji
    Kim, Ja-Eun
    CELL CYCLE, 2014, 13 (05) : 726 - 738
  • [35] The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure
    Jones, Brendan
    Su, Hui
    Bhat, Audesh
    Lei, Hong
    Bajko, Jeffrey
    Hevi, Sarah
    Baltus, Gretchen A.
    Kadam, Shilpa
    Zhai, Huili
    Valdez, Reginald
    Gonzalo, Susana
    Zhang, Yi
    Li, En
    Chen, Taiping
    PLOS GENETICS, 2008, 4 (09)
  • [36] H1 linker histone promotes epigenetic silencing by regulating both DNA methylation and histone H3 methylation
    Yang, Seung-Min
    Kim, Byung Ju
    Toro, Laura Norwood
    Skoultchi, Arthur I.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (05) : 1708 - 1713
  • [37] Deficiency of H3K79 Histone Methyltransferase Dot1-like Protein (DOT1L) Inhibits Cell Proliferation
    Kim, Wootae
    Kim, Ranah
    Park, Geunyeong
    Park, Jong-Wan
    Kim, Ja-Eun
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (08) : 5588 - 5599
  • [38] Crosstalk of homocysteinylation, methylation and acetylation on histone H3
    Xu, Leilei
    Chen, Jiajia
    Gao, Jun
    Yu, Hongxiu
    Yang, Pengyuan
    ANALYST, 2015, 140 (09) : 3057 - 3063
  • [39] Effects of histone H3 methylation on transcription regulation
    Martin, AM
    Wyrick, JJ
    FASEB JOURNAL, 2004, 18 (08): : C84 - C84
  • [40] Arsenite alters global histone H3 methylation
    Zhou, Xue
    Sun, Hong
    Ellen, Thomas P.
    Chen, Haobin
    Costa, Max
    CARCINOGENESIS, 2008, 29 (09) : 1831 - 1836